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Inositol-requiring enzyme 1α/X-box protein 1 pathway expression is impaired in pediatric cholestatic liver disease explants

BACKGROUND: Increased intrahepatic bile acids cause endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) is activated to maintain homeostasis. UPR dysregulation, including the inositol-requiring enzyme 1α/X-box protein 1 (IRE1α/XBP1) pathway, is associated with adult liver disea...

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Detalles Bibliográficos
Autores principales:	Kriegermeier, Alyssa, Hyon, Angela, LeCuyer, Brian, Hubchak, Susan, Liu, Xiaoying, Green, Richard M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754178/ https://www.ncbi.nlm.nih.gov/pubmed/36520816 http://dx.doi.org/10.1371/journal.pone.0279016

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