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Spatial characterization of the effect of age and sex on macular layer thicknesses and foveal pit morphology

Characterizing the effect of age and sex on macular retinal layer thicknesses and foveal pit morphology is crucial to differentiating between natural and disease-related changes. We applied advanced image analysis techniques to optical coherence tomography (OCT) to: 1) enhance the spatial descriptio...

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Autores principales: Romero-Bascones, David, Ayala, Unai, Alberdi, Ane, Erramuzpe, Asier, Galdós, Marta, Gómez-Esteban, Juan Carlos, Murueta-Goyena, Ane, Teijeira, Sara, Gabilondo, Iñigo, Barrenechea, Maitane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754220/
https://www.ncbi.nlm.nih.gov/pubmed/36520804
http://dx.doi.org/10.1371/journal.pone.0278925
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author Romero-Bascones, David
Ayala, Unai
Alberdi, Ane
Erramuzpe, Asier
Galdós, Marta
Gómez-Esteban, Juan Carlos
Murueta-Goyena, Ane
Teijeira, Sara
Gabilondo, Iñigo
Barrenechea, Maitane
author_facet Romero-Bascones, David
Ayala, Unai
Alberdi, Ane
Erramuzpe, Asier
Galdós, Marta
Gómez-Esteban, Juan Carlos
Murueta-Goyena, Ane
Teijeira, Sara
Gabilondo, Iñigo
Barrenechea, Maitane
author_sort Romero-Bascones, David
collection PubMed
description Characterizing the effect of age and sex on macular retinal layer thicknesses and foveal pit morphology is crucial to differentiating between natural and disease-related changes. We applied advanced image analysis techniques to optical coherence tomography (OCT) to: 1) enhance the spatial description of age and sex effects, and 2) create a detailed open database of normative retinal layer thickness maps and foveal pit shapes. The maculae of 444 healthy subjects (age range 21–88) were imaged with OCT. Using computational spatial data analysis, thickness maps were obtained for retinal layers and averaged into 400 (20 x 20) sectors. Additionally, the geometry of the foveal pit was radially analyzed by computing the central foveal thickness, rim height, rim radius, and mean slope. The effect of age and sex on these parameters was analyzed with multiple regression mixed-effects models. We observed that the overall age-related decrease of the total retinal thickness (TRT) (-1.1% per 10 years) was mainly driven by the ganglion cell-inner plexiform layer (GCIPL) (-2.4% per 10 years). Both TRT and GCIPL thinning patterns were homogeneous across the macula when using percentual measurements. Although the male retina was 4.1 μm thicker on average, the greatest differences were mainly present for the inner retinal layers in the inner macular ring (up to 4% higher TRT than in the central macula). There was an age-related decrease in the rim height (1.0% per 10 years) and males had a higher rim height, shorter rim radius, and steeper mean slope. Importantly, the radial analysis revealed that these changes are present and relatively uniform across angular directions. These findings demonstrate the capacity of advanced analysis of OCT images to enhance the description of the macula. This, together with the created dataset, could aid the development of more accurate diagnosis models for macular pathologies.
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spelling pubmed-97542202022-12-16 Spatial characterization of the effect of age and sex on macular layer thicknesses and foveal pit morphology Romero-Bascones, David Ayala, Unai Alberdi, Ane Erramuzpe, Asier Galdós, Marta Gómez-Esteban, Juan Carlos Murueta-Goyena, Ane Teijeira, Sara Gabilondo, Iñigo Barrenechea, Maitane PLoS One Research Article Characterizing the effect of age and sex on macular retinal layer thicknesses and foveal pit morphology is crucial to differentiating between natural and disease-related changes. We applied advanced image analysis techniques to optical coherence tomography (OCT) to: 1) enhance the spatial description of age and sex effects, and 2) create a detailed open database of normative retinal layer thickness maps and foveal pit shapes. The maculae of 444 healthy subjects (age range 21–88) were imaged with OCT. Using computational spatial data analysis, thickness maps were obtained for retinal layers and averaged into 400 (20 x 20) sectors. Additionally, the geometry of the foveal pit was radially analyzed by computing the central foveal thickness, rim height, rim radius, and mean slope. The effect of age and sex on these parameters was analyzed with multiple regression mixed-effects models. We observed that the overall age-related decrease of the total retinal thickness (TRT) (-1.1% per 10 years) was mainly driven by the ganglion cell-inner plexiform layer (GCIPL) (-2.4% per 10 years). Both TRT and GCIPL thinning patterns were homogeneous across the macula when using percentual measurements. Although the male retina was 4.1 μm thicker on average, the greatest differences were mainly present for the inner retinal layers in the inner macular ring (up to 4% higher TRT than in the central macula). There was an age-related decrease in the rim height (1.0% per 10 years) and males had a higher rim height, shorter rim radius, and steeper mean slope. Importantly, the radial analysis revealed that these changes are present and relatively uniform across angular directions. These findings demonstrate the capacity of advanced analysis of OCT images to enhance the description of the macula. This, together with the created dataset, could aid the development of more accurate diagnosis models for macular pathologies. Public Library of Science 2022-12-15 /pmc/articles/PMC9754220/ /pubmed/36520804 http://dx.doi.org/10.1371/journal.pone.0278925 Text en © 2022 Romero-Bascones et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Romero-Bascones, David
Ayala, Unai
Alberdi, Ane
Erramuzpe, Asier
Galdós, Marta
Gómez-Esteban, Juan Carlos
Murueta-Goyena, Ane
Teijeira, Sara
Gabilondo, Iñigo
Barrenechea, Maitane
Spatial characterization of the effect of age and sex on macular layer thicknesses and foveal pit morphology
title Spatial characterization of the effect of age and sex on macular layer thicknesses and foveal pit morphology
title_full Spatial characterization of the effect of age and sex on macular layer thicknesses and foveal pit morphology
title_fullStr Spatial characterization of the effect of age and sex on macular layer thicknesses and foveal pit morphology
title_full_unstemmed Spatial characterization of the effect of age and sex on macular layer thicknesses and foveal pit morphology
title_short Spatial characterization of the effect of age and sex on macular layer thicknesses and foveal pit morphology
title_sort spatial characterization of the effect of age and sex on macular layer thicknesses and foveal pit morphology
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754220/
https://www.ncbi.nlm.nih.gov/pubmed/36520804
http://dx.doi.org/10.1371/journal.pone.0278925
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