An amino-terminal fragment of apolipoprotein E4 leads to behavioral deficits, increased PHF-1 immunoreactivity, and mortality in zebrafish

Although the increased risk of developing sporadic Alzheimer’s disease (AD) associated with the inheritance of the apolipoprotein E4 (APOE4) allele is well characterized, the molecular underpinnings of how ApoE4 imparts risk remains unknown. Enhanced proteolysis of the ApoE4 protein with a toxic-gai...

Descripción completa

Detalles Bibliográficos
Autores principales: McCarthy, Madyson M., Hardy, Makenna J., Leising, Saylor E., LaFollette, Alex M., Stewart, Erica S., Cogan, Amelia S., Sanghal, Tanya, Matteo, Katie, Reeck, Jonathon C., Oxford, Julia T., Rohn, Troy T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754248/
https://www.ncbi.nlm.nih.gov/pubmed/36520946
http://dx.doi.org/10.1371/journal.pone.0271707

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754248/
https://www.ncbi.nlm.nih.gov/pubmed/36520946
http://dx.doi.org/10.1371/journal.pone.0271707

Ejemplares similares