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Identification of genetic variants of the industrial yeast Komagataella phaffii (Pichia pastoris) that contribute to increased yields of secreted heterologous proteins

The yeast Komagataella phaffii (formerly called Pichia pastoris) is used widely as a host for secretion of heterologous proteins, but only a few isolates of this species exist and all the commonly used expression systems are derived from a single genetic background, CBS7435 (NRRL Y-11430). We hypoth...

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Detalles Bibliográficos
Autores principales:	Offei, Benjamin, Braun-Galleani, Stephanie, Venkatesh, Anjan, Casey, William T., O’Connor, Kevin E., Byrne, Kevin P., Wolfe, Kenneth H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754263/ https://www.ncbi.nlm.nih.gov/pubmed/36520709 http://dx.doi.org/10.1371/journal.pbio.3001877

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