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HSP70 inhibitors upregulate prostaglandin E(1)-induced synthesis of interleukin-6 in osteoblasts

Interleukin-6 (IL-6) is a pro-inflammatory and bone-resorptive cytokine that also regulates bone formation. We previously showed that prostaglandin E(1) (PGE(1)) induces the synthesis of IL-6 by activating p44/p42 mitogen-activated protein kinase (MAPK), stress-activated protein kinase/c-Jun N-termi...

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Detalles Bibliográficos
Autores principales:	Kuroyanagi, Gen, Tachi, Junko, Fujita, Kazuhiko, Kawabata, Tetsu, Sakai, Go, Nakashima, Daiki, Kim, Woo, Tanabe, Kumiko, Matsushima-Nishiwaki, Rie, Otsuka, Takanobu, Iida, Hiroki, Kozawa, Osamu, Tokuda, Haruhiko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754267/ https://www.ncbi.nlm.nih.gov/pubmed/36520821 http://dx.doi.org/10.1371/journal.pone.0279134

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