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Pre-operative systemic inflammatory response index influences long-term survival rate in off-pump surgical revascularization

Coronary artery bypass revascularization is still the optimal treatment for complex coronary artery disease with good long-term results. The relation between inflammatory activation in the post-operative period and the long-term prognosis was already postulated. The possible predictive role of preop...

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Autores principales: Urbanowicz, Tomasz, Olasińska-Wiśniewska, Anna, Michalak, Michał, Perek, Bartłomiej, Al-Imam, Ahmed, Rodzki, Michał, Witkowska, Anna, Straburzyńska-Migaj, Ewa, Bociański, Michał, Misterski, Marcin, Lesiak, Maciej, Jemielity, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754600/
https://www.ncbi.nlm.nih.gov/pubmed/36520919
http://dx.doi.org/10.1371/journal.pone.0276138
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author Urbanowicz, Tomasz
Olasińska-Wiśniewska, Anna
Michalak, Michał
Perek, Bartłomiej
Al-Imam, Ahmed
Rodzki, Michał
Witkowska, Anna
Straburzyńska-Migaj, Ewa
Bociański, Michał
Misterski, Marcin
Lesiak, Maciej
Jemielity, Marek
author_facet Urbanowicz, Tomasz
Olasińska-Wiśniewska, Anna
Michalak, Michał
Perek, Bartłomiej
Al-Imam, Ahmed
Rodzki, Michał
Witkowska, Anna
Straburzyńska-Migaj, Ewa
Bociański, Michał
Misterski, Marcin
Lesiak, Maciej
Jemielity, Marek
author_sort Urbanowicz, Tomasz
collection PubMed
description Coronary artery bypass revascularization is still the optimal treatment for complex coronary artery disease with good long-term results. The relation between inflammatory activation in the post-operative period and the long-term prognosis was already postulated. The possible predictive role of preoperative inflammatory indexes after the off-pump coronary artery bypass grafting technique on long term survival was the aim of the study. Study population included 171 patients with a median age of 64 years (59–64) operated on using off-pump technique between January and December 2014. Patients enrolled in the current study were followed-up for 8 years. We conducted a multivariable analysis of pre-operative and post-operative inflammatory markers based on analysis of the whole blood count. The overall survival rate was 80% for the total follow-up period, while 34 deaths were reported (30-days mortality rate of 1%). In the multivariable analysis, a pre-operative value of systemic inflammatory response index (SIRI) >1.27 (HR = 6.16, 95% CI 2.17–17.48, p = 0.012) revealed a prognostic value for long-term mortality assessment after off-pump surgery. Preoperative inflammatory activation evaluated by systemic inflammatory reaction index (SIRI) possess a prognostic value for patients with complex coronary artery disease. The SIRI value above 1.27 indicates a worse late prognosis after off-pump coronary artery bypass (AUC = 0.682, p<0.001).
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spelling pubmed-97546002022-12-16 Pre-operative systemic inflammatory response index influences long-term survival rate in off-pump surgical revascularization Urbanowicz, Tomasz Olasińska-Wiśniewska, Anna Michalak, Michał Perek, Bartłomiej Al-Imam, Ahmed Rodzki, Michał Witkowska, Anna Straburzyńska-Migaj, Ewa Bociański, Michał Misterski, Marcin Lesiak, Maciej Jemielity, Marek PLoS One Research Article Coronary artery bypass revascularization is still the optimal treatment for complex coronary artery disease with good long-term results. The relation between inflammatory activation in the post-operative period and the long-term prognosis was already postulated. The possible predictive role of preoperative inflammatory indexes after the off-pump coronary artery bypass grafting technique on long term survival was the aim of the study. Study population included 171 patients with a median age of 64 years (59–64) operated on using off-pump technique between January and December 2014. Patients enrolled in the current study were followed-up for 8 years. We conducted a multivariable analysis of pre-operative and post-operative inflammatory markers based on analysis of the whole blood count. The overall survival rate was 80% for the total follow-up period, while 34 deaths were reported (30-days mortality rate of 1%). In the multivariable analysis, a pre-operative value of systemic inflammatory response index (SIRI) >1.27 (HR = 6.16, 95% CI 2.17–17.48, p = 0.012) revealed a prognostic value for long-term mortality assessment after off-pump surgery. Preoperative inflammatory activation evaluated by systemic inflammatory reaction index (SIRI) possess a prognostic value for patients with complex coronary artery disease. The SIRI value above 1.27 indicates a worse late prognosis after off-pump coronary artery bypass (AUC = 0.682, p<0.001). Public Library of Science 2022-12-15 /pmc/articles/PMC9754600/ /pubmed/36520919 http://dx.doi.org/10.1371/journal.pone.0276138 Text en © 2022 Urbanowicz et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Urbanowicz, Tomasz
Olasińska-Wiśniewska, Anna
Michalak, Michał
Perek, Bartłomiej
Al-Imam, Ahmed
Rodzki, Michał
Witkowska, Anna
Straburzyńska-Migaj, Ewa
Bociański, Michał
Misterski, Marcin
Lesiak, Maciej
Jemielity, Marek
Pre-operative systemic inflammatory response index influences long-term survival rate in off-pump surgical revascularization
title Pre-operative systemic inflammatory response index influences long-term survival rate in off-pump surgical revascularization
title_full Pre-operative systemic inflammatory response index influences long-term survival rate in off-pump surgical revascularization
title_fullStr Pre-operative systemic inflammatory response index influences long-term survival rate in off-pump surgical revascularization
title_full_unstemmed Pre-operative systemic inflammatory response index influences long-term survival rate in off-pump surgical revascularization
title_short Pre-operative systemic inflammatory response index influences long-term survival rate in off-pump surgical revascularization
title_sort pre-operative systemic inflammatory response index influences long-term survival rate in off-pump surgical revascularization
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754600/
https://www.ncbi.nlm.nih.gov/pubmed/36520919
http://dx.doi.org/10.1371/journal.pone.0276138
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