Germline and somatic variants in ovarian carcinoma: A next-generation sequencing (NGS) analysis

BACKGROUND: Germline BRCA1/2 mutations are identified in 13-15% of ovarian cancers, while an additional 5-7% of ovarian cancers harbor somatic BRCA1/2 mutations. Beyond these mutations, germline or somatic aberrations in genes of the homologous recombination (HR) pathway such as RAD51B/C/D, PALB2, A...

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Detalles Bibliográficos
Autores principales: Andrikopoulou, Angeliki, Zografos, Eleni, Apostolidou, Kleoniki, Kyriazoglou, Anastasios, Papatheodoridi, Alksistis-Maria, Kaparelou, Maria, Koutsoukos, Konstantinos, Liontos, Michalis, Dimopoulos, Meletios-Athanasios, Zagouri, Flora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754718/
https://www.ncbi.nlm.nih.gov/pubmed/36531003
http://dx.doi.org/10.3389/fonc.2022.1030786

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