Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease With False-Positive Results in SARS-CoV-2 Antigen Tests: A Case Report

A 23-year-old man presented with headache, fever, and urinary retention. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen tests were positive, but SARS-CoV-2 polymerase chain reaction (PCR) results were negative. MRI showed long spinal cord lesions. Due to positive serum and cere...

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Autores principales: Yamamoto, Naoki, Ikenouchi, Hajime, Takai, Yoshiki, Endo, Kaoru, Aoki, Masashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754736/
https://www.ncbi.nlm.nih.gov/pubmed/36540506
http://dx.doi.org/10.7759/cureus.31514
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author Yamamoto, Naoki
Ikenouchi, Hajime
Takai, Yoshiki
Endo, Kaoru
Aoki, Masashi
author_facet Yamamoto, Naoki
Ikenouchi, Hajime
Takai, Yoshiki
Endo, Kaoru
Aoki, Masashi
author_sort Yamamoto, Naoki
collection PubMed
description A 23-year-old man presented with headache, fever, and urinary retention. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen tests were positive, but SARS-CoV-2 polymerase chain reaction (PCR) results were negative. MRI showed long spinal cord lesions. Due to positive serum and cerebrospinal fluid myelin oligodendrocyte glycoprotein (MOG) antibodies, we made the diagnosis of MOG-associated disease. We concluded that the antigen tests were false positives because SARS-CoV-2 IgM and IgG were not elevated. Although the mechanism behind the false-positive results is unclear, physicians should consider the possibility of a false-positive result in the SARS-CoV-2 antigen test.
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spelling pubmed-97547362022-12-19 Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease With False-Positive Results in SARS-CoV-2 Antigen Tests: A Case Report Yamamoto, Naoki Ikenouchi, Hajime Takai, Yoshiki Endo, Kaoru Aoki, Masashi Cureus Neurology A 23-year-old man presented with headache, fever, and urinary retention. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen tests were positive, but SARS-CoV-2 polymerase chain reaction (PCR) results were negative. MRI showed long spinal cord lesions. Due to positive serum and cerebrospinal fluid myelin oligodendrocyte glycoprotein (MOG) antibodies, we made the diagnosis of MOG-associated disease. We concluded that the antigen tests were false positives because SARS-CoV-2 IgM and IgG were not elevated. Although the mechanism behind the false-positive results is unclear, physicians should consider the possibility of a false-positive result in the SARS-CoV-2 antigen test. Cureus 2022-11-14 /pmc/articles/PMC9754736/ /pubmed/36540506 http://dx.doi.org/10.7759/cureus.31514 Text en Copyright © 2022, Yamamoto et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Neurology
Yamamoto, Naoki
Ikenouchi, Hajime
Takai, Yoshiki
Endo, Kaoru
Aoki, Masashi
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease With False-Positive Results in SARS-CoV-2 Antigen Tests: A Case Report
title Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease With False-Positive Results in SARS-CoV-2 Antigen Tests: A Case Report
title_full Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease With False-Positive Results in SARS-CoV-2 Antigen Tests: A Case Report
title_fullStr Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease With False-Positive Results in SARS-CoV-2 Antigen Tests: A Case Report
title_full_unstemmed Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease With False-Positive Results in SARS-CoV-2 Antigen Tests: A Case Report
title_short Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease With False-Positive Results in SARS-CoV-2 Antigen Tests: A Case Report
title_sort myelin oligodendrocyte glycoprotein antibody-associated disease with false-positive results in sars-cov-2 antigen tests: a case report
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754736/
https://www.ncbi.nlm.nih.gov/pubmed/36540506
http://dx.doi.org/10.7759/cureus.31514
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