Metagenomic Next-Generation Sequencing (mNGS) for the Timely Diagnosis of Carbapenem-Resistant Klebsiella pneumoniae in Leukemia Patients

This report shows the contribution of metagenomic next-generation sequencing (mNGS) as an alternative to challenging diagnostic infection in immunosuppressed individuals. Herein, we report two leukemia patients who developed severe infections due to carbapenem-resistant Klebsiella pneumoniae (CrKP)....

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Detalles Bibliográficos
Autores principales: Tao, Huan, Hua, Fang, Chen, Yingying, Jia, Yongqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754844/
https://www.ncbi.nlm.nih.gov/pubmed/36531828
http://dx.doi.org/10.1155/2022/6957028
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author Tao, Huan
Hua, Fang
Chen, Yingying
Jia, Yongqian
author_facet Tao, Huan
Hua, Fang
Chen, Yingying
Jia, Yongqian
author_sort Tao, Huan
collection PubMed
description This report shows the contribution of metagenomic next-generation sequencing (mNGS) as an alternative to challenging diagnostic infection in immunosuppressed individuals. Herein, we report two leukemia patients who developed severe infections due to carbapenem-resistant Klebsiella pneumoniae (CrKP). The mNGS can be strongly recommended as an alternative investigation for patients who are at high risk of infection without positivity on body fluid culture. This can provide the opportunity for adequate therapy.
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spelling pubmed-97548442022-12-16 Metagenomic Next-Generation Sequencing (mNGS) for the Timely Diagnosis of Carbapenem-Resistant Klebsiella pneumoniae in Leukemia Patients Tao, Huan Hua, Fang Chen, Yingying Jia, Yongqian Case Rep Infect Dis Case Report This report shows the contribution of metagenomic next-generation sequencing (mNGS) as an alternative to challenging diagnostic infection in immunosuppressed individuals. Herein, we report two leukemia patients who developed severe infections due to carbapenem-resistant Klebsiella pneumoniae (CrKP). The mNGS can be strongly recommended as an alternative investigation for patients who are at high risk of infection without positivity on body fluid culture. This can provide the opportunity for adequate therapy. Hindawi 2022-12-08 /pmc/articles/PMC9754844/ /pubmed/36531828 http://dx.doi.org/10.1155/2022/6957028 Text en Copyright © 2022 Huan Tao et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Tao, Huan
Hua, Fang
Chen, Yingying
Jia, Yongqian
Metagenomic Next-Generation Sequencing (mNGS) for the Timely Diagnosis of Carbapenem-Resistant Klebsiella pneumoniae in Leukemia Patients
title Metagenomic Next-Generation Sequencing (mNGS) for the Timely Diagnosis of Carbapenem-Resistant Klebsiella pneumoniae in Leukemia Patients
title_full Metagenomic Next-Generation Sequencing (mNGS) for the Timely Diagnosis of Carbapenem-Resistant Klebsiella pneumoniae in Leukemia Patients
title_fullStr Metagenomic Next-Generation Sequencing (mNGS) for the Timely Diagnosis of Carbapenem-Resistant Klebsiella pneumoniae in Leukemia Patients
title_full_unstemmed Metagenomic Next-Generation Sequencing (mNGS) for the Timely Diagnosis of Carbapenem-Resistant Klebsiella pneumoniae in Leukemia Patients
title_short Metagenomic Next-Generation Sequencing (mNGS) for the Timely Diagnosis of Carbapenem-Resistant Klebsiella pneumoniae in Leukemia Patients
title_sort metagenomic next-generation sequencing (mngs) for the timely diagnosis of carbapenem-resistant klebsiella pneumoniae in leukemia patients
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9754844/
https://www.ncbi.nlm.nih.gov/pubmed/36531828
http://dx.doi.org/10.1155/2022/6957028
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