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(2R,6R)-hydroxynorketamine acts through GluA1-induced synaptic plasticity to alleviate PTSD-like effects in rat models
Post-traumatic stress disorder (PTSD) is a debilitating mental disorder with high morbidity and great social and economic relevance. However, extant pharmacotherapies of PTSD require long-term use to maintain effectiveness and have enormous side effects. The glutamatergic system, especially the α-am...
Autores principales: | Li, Yu, Du, YaLin, Wang, Chen, Lu, GuoHua, Sun, HongWei, Kong, YuJia, Wang, WeiWen, Lian, Bo, Li, ChangJiang, Wang, Ling, Zhang, XianQiang, Sun, Lin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755068/ https://www.ncbi.nlm.nih.gov/pubmed/36532380 http://dx.doi.org/10.1016/j.ynstr.2022.100503 |
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