Achieving single nucleotide sensitivity in direct hybridization genome imaging

Direct visualization of point mutations in situ can be informative for studying genetic diseases and nuclear biology. We describe a direct hybridization genome imaging method with single-nucleotide sensitivity, single guide genome oligopaint via local denaturation fluorescence in situ hybridization...

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Detalles Bibliográficos
Autores principales: Wang, Yanbo, Cottle, W. Taylor, Wang, Haobo, Gavrilov, Momcilo, Zou, Roger S., Pham, Minh-Tam, Yegnasubramanian, Srinivasan, Bailey, Scott, Ha, Taekjip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755149/
https://www.ncbi.nlm.nih.gov/pubmed/36522352
http://dx.doi.org/10.1038/s41467-022-35476-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755149/
https://www.ncbi.nlm.nih.gov/pubmed/36522352
http://dx.doi.org/10.1038/s41467-022-35476-y

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