Loss-of-function N178T variant of the human P2Y(4) receptor is associated with decreased severity of coronary artery disease and improved glucose homeostasis

Human P2Y(4) is a UTP receptor, while in mice it is activated by both ATP and UTP. P2Y(4) knockout (KO) in mice protects against myocardial infarction and is characterized by increased adiponectin secretion by adipocytes, and decreased cardiac inflammation and permeability under ischemic conditions....

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Detalles Bibliográficos
Autores principales: Horckmans, Michael, Diaz Villamil, Esteban, Verdier, Céline, Laurell, Henrik, Ruidavets, Jean-Bernard, De Roeck, Lucas, Combes, Guillaume, Martinez, Laurent O., Communi, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755162/
https://www.ncbi.nlm.nih.gov/pubmed/36532779
http://dx.doi.org/10.3389/fphar.2022.1049696

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