The interplay between cardiac dyads and mitochondria regulated the calcium handling in cardiomyocytes

Calcium mishandling and mitochondrial dysfunction have been increasingly recognized as significant factors involved in the progression procedure of cardiomyopathy. Ca2+ mishandling could cause calcium-triggered arrhythmias, which could enhance force development and ATP consumption. Mitochondrial dis...

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Autores principales: Liu, Lei, Zhou, Kaiyu, Liu, Xiaoliang, Hua, Yimin, Wang, Hua, Li, Yifei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755166/
https://www.ncbi.nlm.nih.gov/pubmed/36531185
http://dx.doi.org/10.3389/fphys.2022.1013817
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author Liu, Lei
Zhou, Kaiyu
Liu, Xiaoliang
Hua, Yimin
Wang, Hua
Li, Yifei
author_facet Liu, Lei
Zhou, Kaiyu
Liu, Xiaoliang
Hua, Yimin
Wang, Hua
Li, Yifei
author_sort Liu, Lei
collection PubMed
description Calcium mishandling and mitochondrial dysfunction have been increasingly recognized as significant factors involved in the progression procedure of cardiomyopathy. Ca2+ mishandling could cause calcium-triggered arrhythmias, which could enhance force development and ATP consumption. Mitochondrial disorganization and dysfunction in cardiomyopathy could disturb the balance of energy catabolic and anabolic procedure. Close spatial localization and arrangement of structural among T-tubule, sarcoplasmic reticulum, mitochondria are important for Ca2+ handling. So that, we illustrate the regulating network between calcium handling and mitochondrial homeostasis, as well as its intracellular mechanisms in this review, which would be worthy to develop novel therapeutic strategy and restore the function of injured cardiomyocytes.
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spelling pubmed-97551662022-12-17 The interplay between cardiac dyads and mitochondria regulated the calcium handling in cardiomyocytes Liu, Lei Zhou, Kaiyu Liu, Xiaoliang Hua, Yimin Wang, Hua Li, Yifei Front Physiol Physiology Calcium mishandling and mitochondrial dysfunction have been increasingly recognized as significant factors involved in the progression procedure of cardiomyopathy. Ca2+ mishandling could cause calcium-triggered arrhythmias, which could enhance force development and ATP consumption. Mitochondrial disorganization and dysfunction in cardiomyopathy could disturb the balance of energy catabolic and anabolic procedure. Close spatial localization and arrangement of structural among T-tubule, sarcoplasmic reticulum, mitochondria are important for Ca2+ handling. So that, we illustrate the regulating network between calcium handling and mitochondrial homeostasis, as well as its intracellular mechanisms in this review, which would be worthy to develop novel therapeutic strategy and restore the function of injured cardiomyocytes. Frontiers Media S.A. 2022-12-02 /pmc/articles/PMC9755166/ /pubmed/36531185 http://dx.doi.org/10.3389/fphys.2022.1013817 Text en Copyright © 2022 Liu, Zhou, Liu, Hua, Wang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Liu, Lei
Zhou, Kaiyu
Liu, Xiaoliang
Hua, Yimin
Wang, Hua
Li, Yifei
The interplay between cardiac dyads and mitochondria regulated the calcium handling in cardiomyocytes
title The interplay between cardiac dyads and mitochondria regulated the calcium handling in cardiomyocytes
title_full The interplay between cardiac dyads and mitochondria regulated the calcium handling in cardiomyocytes
title_fullStr The interplay between cardiac dyads and mitochondria regulated the calcium handling in cardiomyocytes
title_full_unstemmed The interplay between cardiac dyads and mitochondria regulated the calcium handling in cardiomyocytes
title_short The interplay between cardiac dyads and mitochondria regulated the calcium handling in cardiomyocytes
title_sort interplay between cardiac dyads and mitochondria regulated the calcium handling in cardiomyocytes
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755166/
https://www.ncbi.nlm.nih.gov/pubmed/36531185
http://dx.doi.org/10.3389/fphys.2022.1013817
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