Understanding inter-individual variability in pharmacokinetics/pharmacodynamics of aripiprazole in children with tic disorders: Individualized administration based on physiological development and CYP2D6 genotypes

Objective: This study aims to develop a combined population pharmacokinetic (PPK) model for aripiprazole (ARI) and its main active metabolite dehydroaripiprazole (DARI) in pediatric patients with tic disorders (TD), to investigate the inter-individual variability caused by physiological and genetic...

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Detalles Bibliográficos
Autores principales: Xin, Yingying, Gao, Liuliu, Tuo, Yali, Nie, Gang, Mei, Yan, Chen, Chen, Wang, Jun, Li, Sichan, Sun, Dan, Qian, Qiaoqiao, Fu, Yongli, Wang, Yang, Liu, Zhisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755210/
https://www.ncbi.nlm.nih.gov/pubmed/36532742
http://dx.doi.org/10.3389/fphar.2022.1048498

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