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An investigation of metabolome in blood in patients with chronic peripheral, posttraumatic/postsurgical neuropathic pain

Neuropathic pain (NP) is a chronic pain condition resulting from a lesion or disease in the somatosensory nervous system. The aim of this study was to investigate the metabolome in plasma from patients with chronic peripheral, posttraumatic/postsurgical NP compared to healthy controls. Further, we a...

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Autores principales: Ghafouri, Bijar, Thordeman, Katarina, Hadjikani, Romina, Bay Nord, Anders, Gerdle, Björn, Bäckryd, Emmanuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755304/
https://www.ncbi.nlm.nih.gov/pubmed/36522472
http://dx.doi.org/10.1038/s41598-022-26405-6
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author Ghafouri, Bijar
Thordeman, Katarina
Hadjikani, Romina
Bay Nord, Anders
Gerdle, Björn
Bäckryd, Emmanuel
author_facet Ghafouri, Bijar
Thordeman, Katarina
Hadjikani, Romina
Bay Nord, Anders
Gerdle, Björn
Bäckryd, Emmanuel
author_sort Ghafouri, Bijar
collection PubMed
description Neuropathic pain (NP) is a chronic pain condition resulting from a lesion or disease in the somatosensory nervous system. The aim of this study was to investigate the metabolome in plasma from patients with chronic peripheral, posttraumatic/postsurgical NP compared to healthy controls. Further, we aimed to investigate the correlation between pain intensity and the metabolome in plasma. The metabolic profile in plasma samples from 16 patients with chronic NP and 12 healthy controls was analyzed using a nuclear magnetic resonance spectroscopy method. Information about pain intensity, pain duration, body mass index (BMI), age, sex, and blood pressure were obtained through a questionnaire and clinical examination. Multivariate data analysis was used to identify metabolites significant for group separation and their correlation with pain intensity and duration, BMI, and age. We found 50 out of 326 features in plasma significantly contributing to group discrimination between NP and controls. Several of the metabolites that significantly differed were involved in inflammatory processes, while others were important for central nervous system functioning and neural signaling. There was no correlation between pain intensity and levels of metabolite in NP. These findings indicate that there seems to be peripheral/systemic differences in the metabolic profile between patients with chronic NP and healthy individuals.
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spelling pubmed-97553042022-12-17 An investigation of metabolome in blood in patients with chronic peripheral, posttraumatic/postsurgical neuropathic pain Ghafouri, Bijar Thordeman, Katarina Hadjikani, Romina Bay Nord, Anders Gerdle, Björn Bäckryd, Emmanuel Sci Rep Article Neuropathic pain (NP) is a chronic pain condition resulting from a lesion or disease in the somatosensory nervous system. The aim of this study was to investigate the metabolome in plasma from patients with chronic peripheral, posttraumatic/postsurgical NP compared to healthy controls. Further, we aimed to investigate the correlation between pain intensity and the metabolome in plasma. The metabolic profile in plasma samples from 16 patients with chronic NP and 12 healthy controls was analyzed using a nuclear magnetic resonance spectroscopy method. Information about pain intensity, pain duration, body mass index (BMI), age, sex, and blood pressure were obtained through a questionnaire and clinical examination. Multivariate data analysis was used to identify metabolites significant for group separation and their correlation with pain intensity and duration, BMI, and age. We found 50 out of 326 features in plasma significantly contributing to group discrimination between NP and controls. Several of the metabolites that significantly differed were involved in inflammatory processes, while others were important for central nervous system functioning and neural signaling. There was no correlation between pain intensity and levels of metabolite in NP. These findings indicate that there seems to be peripheral/systemic differences in the metabolic profile between patients with chronic NP and healthy individuals. Nature Publishing Group UK 2022-12-15 /pmc/articles/PMC9755304/ /pubmed/36522472 http://dx.doi.org/10.1038/s41598-022-26405-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Ghafouri, Bijar
Thordeman, Katarina
Hadjikani, Romina
Bay Nord, Anders
Gerdle, Björn
Bäckryd, Emmanuel
An investigation of metabolome in blood in patients with chronic peripheral, posttraumatic/postsurgical neuropathic pain
title An investigation of metabolome in blood in patients with chronic peripheral, posttraumatic/postsurgical neuropathic pain
title_full An investigation of metabolome in blood in patients with chronic peripheral, posttraumatic/postsurgical neuropathic pain
title_fullStr An investigation of metabolome in blood in patients with chronic peripheral, posttraumatic/postsurgical neuropathic pain
title_full_unstemmed An investigation of metabolome in blood in patients with chronic peripheral, posttraumatic/postsurgical neuropathic pain
title_short An investigation of metabolome in blood in patients with chronic peripheral, posttraumatic/postsurgical neuropathic pain
title_sort investigation of metabolome in blood in patients with chronic peripheral, posttraumatic/postsurgical neuropathic pain
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755304/
https://www.ncbi.nlm.nih.gov/pubmed/36522472
http://dx.doi.org/10.1038/s41598-022-26405-6
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