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Manual and semi-automated approaches to MIBG myocardial scintigraphy in patients with Parkinson’s disease

OBJECTIVE: This study investigates the effects of manual and semi-automatic methods for assessing MIBG semi-quantitative indices in a clinical setting. MATERIALS AND METHODS: We included (123)I-MIBG scans obtained in 35 patients with idiopathic Parkinson’s Disease. Early and late heart-to-mediastinu...

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Autores principales: Boccalini, Cecilia, Carli, Giulia, Vanoli, Emilia Giovanna, Cocco, Antoniangela, Albanese, Alberto, Garibotto, Valentina, Perani, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755341/
https://www.ncbi.nlm.nih.gov/pubmed/36530915
http://dx.doi.org/10.3389/fmed.2022.1073720
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author Boccalini, Cecilia
Carli, Giulia
Vanoli, Emilia Giovanna
Cocco, Antoniangela
Albanese, Alberto
Garibotto, Valentina
Perani, Daniela
author_facet Boccalini, Cecilia
Carli, Giulia
Vanoli, Emilia Giovanna
Cocco, Antoniangela
Albanese, Alberto
Garibotto, Valentina
Perani, Daniela
author_sort Boccalini, Cecilia
collection PubMed
description OBJECTIVE: This study investigates the effects of manual and semi-automatic methods for assessing MIBG semi-quantitative indices in a clinical setting. MATERIALS AND METHODS: We included (123)I-MIBG scans obtained in 35 patients with idiopathic Parkinson’s Disease. Early and late heart-to-mediastinum (H/M) ratios were calculated from (123)I-MIBG images using regions of interest (ROIs) placed over the heart and the mediastinum. The ROIs were derived using two approaches: (i) manually drawn and (ii) semi-automatic fixed-size ROIs using anatomical landmarks. Expert, moderate-expert, and not expert raters applied the ROIs procedures and interpreted the (123)I-MIBG images. We evaluated the inter and intra-rater agreements in assessing (123)I-MIBG H/M ratios. RESULTS: A moderate agreement in the raters’ classification of pathological and non-pathological scores emerged regarding early and late H/M ratio values (κ = 0.45 and 0.69 respectively), applying the manual method, while the early and late H/M ratios obtained with the semi-automatic method reached a good agreement among observers (κ = 0.78). Cohen-Kappa values revealed that the semi-automatic method improved the agreement between expert and inexpert raters: the agreement improved from a minimum of 0.29 (fair, for early H/M) and 0.69 (substantial, in late H/M) with the manual method, to 0.90 (perfect, in early H/M) and 0.87 (perfect, in late H/M) with the semi-automatic method. CONCLUSION: The use of the semi-automatic method improves the agreement among raters in classifying’ H/M ratios as pathological or non-pathological, namely for inexpert readers. These results have important implications for semi-quantitative assessment of (123)I-MIBG images in clinical routine.
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spelling pubmed-97553412022-12-17 Manual and semi-automated approaches to MIBG myocardial scintigraphy in patients with Parkinson’s disease Boccalini, Cecilia Carli, Giulia Vanoli, Emilia Giovanna Cocco, Antoniangela Albanese, Alberto Garibotto, Valentina Perani, Daniela Front Med (Lausanne) Medicine OBJECTIVE: This study investigates the effects of manual and semi-automatic methods for assessing MIBG semi-quantitative indices in a clinical setting. MATERIALS AND METHODS: We included (123)I-MIBG scans obtained in 35 patients with idiopathic Parkinson’s Disease. Early and late heart-to-mediastinum (H/M) ratios were calculated from (123)I-MIBG images using regions of interest (ROIs) placed over the heart and the mediastinum. The ROIs were derived using two approaches: (i) manually drawn and (ii) semi-automatic fixed-size ROIs using anatomical landmarks. Expert, moderate-expert, and not expert raters applied the ROIs procedures and interpreted the (123)I-MIBG images. We evaluated the inter and intra-rater agreements in assessing (123)I-MIBG H/M ratios. RESULTS: A moderate agreement in the raters’ classification of pathological and non-pathological scores emerged regarding early and late H/M ratio values (κ = 0.45 and 0.69 respectively), applying the manual method, while the early and late H/M ratios obtained with the semi-automatic method reached a good agreement among observers (κ = 0.78). Cohen-Kappa values revealed that the semi-automatic method improved the agreement between expert and inexpert raters: the agreement improved from a minimum of 0.29 (fair, for early H/M) and 0.69 (substantial, in late H/M) with the manual method, to 0.90 (perfect, in early H/M) and 0.87 (perfect, in late H/M) with the semi-automatic method. CONCLUSION: The use of the semi-automatic method improves the agreement among raters in classifying’ H/M ratios as pathological or non-pathological, namely for inexpert readers. These results have important implications for semi-quantitative assessment of (123)I-MIBG images in clinical routine. Frontiers Media S.A. 2022-12-02 /pmc/articles/PMC9755341/ /pubmed/36530915 http://dx.doi.org/10.3389/fmed.2022.1073720 Text en Copyright © 2022 Boccalini, Carli, Vanoli, Cocco, Albanese, Garibotto and Perani. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Boccalini, Cecilia
Carli, Giulia
Vanoli, Emilia Giovanna
Cocco, Antoniangela
Albanese, Alberto
Garibotto, Valentina
Perani, Daniela
Manual and semi-automated approaches to MIBG myocardial scintigraphy in patients with Parkinson’s disease
title Manual and semi-automated approaches to MIBG myocardial scintigraphy in patients with Parkinson’s disease
title_full Manual and semi-automated approaches to MIBG myocardial scintigraphy in patients with Parkinson’s disease
title_fullStr Manual and semi-automated approaches to MIBG myocardial scintigraphy in patients with Parkinson’s disease
title_full_unstemmed Manual and semi-automated approaches to MIBG myocardial scintigraphy in patients with Parkinson’s disease
title_short Manual and semi-automated approaches to MIBG myocardial scintigraphy in patients with Parkinson’s disease
title_sort manual and semi-automated approaches to mibg myocardial scintigraphy in patients with parkinson’s disease
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755341/
https://www.ncbi.nlm.nih.gov/pubmed/36530915
http://dx.doi.org/10.3389/fmed.2022.1073720
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