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Differential microbiota network in gingival tissues between periodontitis and periodontitis with diabetes
Periodontitis and diabetes mellitus (DM) have a bidirectional relationship. Periodontitis is initiated by dysbiosis of oral microorganisms, and in particular, the characteristics of the microorganisms that have penetrated the tissue are directly related to the disease; therefore, we investigated the...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755495/ https://www.ncbi.nlm.nih.gov/pubmed/36530437 http://dx.doi.org/10.3389/fcimb.2022.1061125 |
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author | Yu, Yeuni Kim, Hyun-Joo Song, Jae-Min Kang, Junho Lee, Hansong Park, Hae Ryoun Kim, Yun Hak |
author_facet | Yu, Yeuni Kim, Hyun-Joo Song, Jae-Min Kang, Junho Lee, Hansong Park, Hae Ryoun Kim, Yun Hak |
author_sort | Yu, Yeuni |
collection | PubMed |
description | Periodontitis and diabetes mellitus (DM) have a bidirectional relationship. Periodontitis is initiated by dysbiosis of oral microorganisms, and in particular, the characteristics of the microorganisms that have penetrated the tissue are directly related to the disease; therefore, we investigated the effect of DM on intragingival microbial profiling of patients with periodontitis. A total of 39 subjects were recruited and divided into three groups in this case control study as follows: healthy (NA, 10), periodontitis only (PD, 18), and periodontitis with DM (PD_DM, 11). Gingival tissue was collected, DNA was extracted, and whole-genome sequencing was performed. PD and PD_DM showed different characteristics from NA in diversity and composition of the microbial community; however, no difference was found between the PD nad PD_DM. PD_DM showed discriminatory characteristics for PD in the network analysis. PD showed a network structure in which six species were connected, including three red complex species, and PD_DM’s network was more closely connected and expanded, with six additional species added to the PD network. Although DM did not significantly affect α- and β-diversity or abundance of phyla and genera of microbiota that invaded the gingival tissue of patients with periodontitis, DM will affect the progression of periodontitis by strengthening the bacterial network in the gingival tissue. |
format | Online Article Text |
id | pubmed-9755495 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97554952022-12-17 Differential microbiota network in gingival tissues between periodontitis and periodontitis with diabetes Yu, Yeuni Kim, Hyun-Joo Song, Jae-Min Kang, Junho Lee, Hansong Park, Hae Ryoun Kim, Yun Hak Front Cell Infect Microbiol Cellular and Infection Microbiology Periodontitis and diabetes mellitus (DM) have a bidirectional relationship. Periodontitis is initiated by dysbiosis of oral microorganisms, and in particular, the characteristics of the microorganisms that have penetrated the tissue are directly related to the disease; therefore, we investigated the effect of DM on intragingival microbial profiling of patients with periodontitis. A total of 39 subjects were recruited and divided into three groups in this case control study as follows: healthy (NA, 10), periodontitis only (PD, 18), and periodontitis with DM (PD_DM, 11). Gingival tissue was collected, DNA was extracted, and whole-genome sequencing was performed. PD and PD_DM showed different characteristics from NA in diversity and composition of the microbial community; however, no difference was found between the PD nad PD_DM. PD_DM showed discriminatory characteristics for PD in the network analysis. PD showed a network structure in which six species were connected, including three red complex species, and PD_DM’s network was more closely connected and expanded, with six additional species added to the PD network. Although DM did not significantly affect α- and β-diversity or abundance of phyla and genera of microbiota that invaded the gingival tissue of patients with periodontitis, DM will affect the progression of periodontitis by strengthening the bacterial network in the gingival tissue. Frontiers Media S.A. 2022-12-02 /pmc/articles/PMC9755495/ /pubmed/36530437 http://dx.doi.org/10.3389/fcimb.2022.1061125 Text en Copyright © 2022 Yu, Kim, Song, Kang, Lee, Park and Kim https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cellular and Infection Microbiology Yu, Yeuni Kim, Hyun-Joo Song, Jae-Min Kang, Junho Lee, Hansong Park, Hae Ryoun Kim, Yun Hak Differential microbiota network in gingival tissues between periodontitis and periodontitis with diabetes |
title | Differential microbiota network in gingival tissues between periodontitis and periodontitis with diabetes |
title_full | Differential microbiota network in gingival tissues between periodontitis and periodontitis with diabetes |
title_fullStr | Differential microbiota network in gingival tissues between periodontitis and periodontitis with diabetes |
title_full_unstemmed | Differential microbiota network in gingival tissues between periodontitis and periodontitis with diabetes |
title_short | Differential microbiota network in gingival tissues between periodontitis and periodontitis with diabetes |
title_sort | differential microbiota network in gingival tissues between periodontitis and periodontitis with diabetes |
topic | Cellular and Infection Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755495/ https://www.ncbi.nlm.nih.gov/pubmed/36530437 http://dx.doi.org/10.3389/fcimb.2022.1061125 |
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