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Autonomic imbalance and atrial ectopic activity—a pathophysiological and clinical view
The heart is one of the most richly innervated organs and the impact of the complex cardiac autonomic network on atrial electrophysiology and arrhythmogenesis, including on atrial ectopy, is widely recognized. The aim of this review is to discuss the main mechanisms involved in atrial ectopic activi...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755506/ https://www.ncbi.nlm.nih.gov/pubmed/36531175 http://dx.doi.org/10.3389/fphys.2022.1058427 |
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author | Scridon, Alina |
author_facet | Scridon, Alina |
author_sort | Scridon, Alina |
collection | PubMed |
description | The heart is one of the most richly innervated organs and the impact of the complex cardiac autonomic network on atrial electrophysiology and arrhythmogenesis, including on atrial ectopy, is widely recognized. The aim of this review is to discuss the main mechanisms involved in atrial ectopic activity. An overview of the anatomic and physiological aspects of the cardiac autonomic nervous system is provided as well as a discussion of the main pathophysiological pathways linking autonomic imbalance and atrial ectopic activity. The most relevant data on cardiac neuromodulation strategies are emphasized. Unanswered questions and hotspots for future research are also identified. |
format | Online Article Text |
id | pubmed-9755506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97555062022-12-17 Autonomic imbalance and atrial ectopic activity—a pathophysiological and clinical view Scridon, Alina Front Physiol Physiology The heart is one of the most richly innervated organs and the impact of the complex cardiac autonomic network on atrial electrophysiology and arrhythmogenesis, including on atrial ectopy, is widely recognized. The aim of this review is to discuss the main mechanisms involved in atrial ectopic activity. An overview of the anatomic and physiological aspects of the cardiac autonomic nervous system is provided as well as a discussion of the main pathophysiological pathways linking autonomic imbalance and atrial ectopic activity. The most relevant data on cardiac neuromodulation strategies are emphasized. Unanswered questions and hotspots for future research are also identified. Frontiers Media S.A. 2022-12-02 /pmc/articles/PMC9755506/ /pubmed/36531175 http://dx.doi.org/10.3389/fphys.2022.1058427 Text en Copyright © 2022 Scridon. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Scridon, Alina Autonomic imbalance and atrial ectopic activity—a pathophysiological and clinical view |
title | Autonomic imbalance and atrial ectopic activity—a pathophysiological and clinical view |
title_full | Autonomic imbalance and atrial ectopic activity—a pathophysiological and clinical view |
title_fullStr | Autonomic imbalance and atrial ectopic activity—a pathophysiological and clinical view |
title_full_unstemmed | Autonomic imbalance and atrial ectopic activity—a pathophysiological and clinical view |
title_short | Autonomic imbalance and atrial ectopic activity—a pathophysiological and clinical view |
title_sort | autonomic imbalance and atrial ectopic activity—a pathophysiological and clinical view |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755506/ https://www.ncbi.nlm.nih.gov/pubmed/36531175 http://dx.doi.org/10.3389/fphys.2022.1058427 |
work_keys_str_mv | AT scridonalina autonomicimbalanceandatrialectopicactivityapathophysiologicalandclinicalview |