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The biological alterations of synapse/synapse formation in sepsis-associated encephalopathy
Sepsis-associated encephalopathy (SAE) is a common complication caused by sepsis, and is responsible for increased mortality and poor outcomes in septic patients. Neurological dysfunction is one of the main manifestations of SAE patients. Patients may still have long-term cognitive impairment after...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755596/ https://www.ncbi.nlm.nih.gov/pubmed/36530954 http://dx.doi.org/10.3389/fnsyn.2022.1054605 |
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author | Tang, Chuan Jin, Ye Wang, Huan |
author_facet | Tang, Chuan Jin, Ye Wang, Huan |
author_sort | Tang, Chuan |
collection | PubMed |
description | Sepsis-associated encephalopathy (SAE) is a common complication caused by sepsis, and is responsible for increased mortality and poor outcomes in septic patients. Neurological dysfunction is one of the main manifestations of SAE patients. Patients may still have long-term cognitive impairment after hospital discharge, and the underlying mechanism is still unclear. Here, we first outline the pathophysiological changes of SAE, including neuroinflammation, glial activation, and blood-brain barrier (BBB) breakdown. Synapse dysfunction is one of the main contributors leading to neurological impairment. Therefore, we summarized SAE-induced synaptic dysfunction, such as synaptic plasticity inhibition, neurotransmitter imbalance, and synapses loss. Finally, we discuss the alterations in the synapse, synapse formation, and mediators associated with synapse formation during SAE. In this review, we focus on the changes in synapse/synapse formation caused by SAE, which can further understand the synaptic dysfunction associated with neurological impairment in SAE and provide important insights for exploring appropriate therapeutic targets of SAE. |
format | Online Article Text |
id | pubmed-9755596 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97555962022-12-17 The biological alterations of synapse/synapse formation in sepsis-associated encephalopathy Tang, Chuan Jin, Ye Wang, Huan Front Synaptic Neurosci Neuroscience Sepsis-associated encephalopathy (SAE) is a common complication caused by sepsis, and is responsible for increased mortality and poor outcomes in septic patients. Neurological dysfunction is one of the main manifestations of SAE patients. Patients may still have long-term cognitive impairment after hospital discharge, and the underlying mechanism is still unclear. Here, we first outline the pathophysiological changes of SAE, including neuroinflammation, glial activation, and blood-brain barrier (BBB) breakdown. Synapse dysfunction is one of the main contributors leading to neurological impairment. Therefore, we summarized SAE-induced synaptic dysfunction, such as synaptic plasticity inhibition, neurotransmitter imbalance, and synapses loss. Finally, we discuss the alterations in the synapse, synapse formation, and mediators associated with synapse formation during SAE. In this review, we focus on the changes in synapse/synapse formation caused by SAE, which can further understand the synaptic dysfunction associated with neurological impairment in SAE and provide important insights for exploring appropriate therapeutic targets of SAE. Frontiers Media S.A. 2022-12-02 /pmc/articles/PMC9755596/ /pubmed/36530954 http://dx.doi.org/10.3389/fnsyn.2022.1054605 Text en Copyright © 2022 Tang, Jin and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Tang, Chuan Jin, Ye Wang, Huan The biological alterations of synapse/synapse formation in sepsis-associated encephalopathy |
title | The biological alterations of synapse/synapse formation in sepsis-associated encephalopathy |
title_full | The biological alterations of synapse/synapse formation in sepsis-associated encephalopathy |
title_fullStr | The biological alterations of synapse/synapse formation in sepsis-associated encephalopathy |
title_full_unstemmed | The biological alterations of synapse/synapse formation in sepsis-associated encephalopathy |
title_short | The biological alterations of synapse/synapse formation in sepsis-associated encephalopathy |
title_sort | biological alterations of synapse/synapse formation in sepsis-associated encephalopathy |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755596/ https://www.ncbi.nlm.nih.gov/pubmed/36530954 http://dx.doi.org/10.3389/fnsyn.2022.1054605 |
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