Cargando…

The biological alterations of synapse/synapse formation in sepsis-associated encephalopathy

Sepsis-associated encephalopathy (SAE) is a common complication caused by sepsis, and is responsible for increased mortality and poor outcomes in septic patients. Neurological dysfunction is one of the main manifestations of SAE patients. Patients may still have long-term cognitive impairment after...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Chuan, Jin, Ye, Wang, Huan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755596/
https://www.ncbi.nlm.nih.gov/pubmed/36530954
http://dx.doi.org/10.3389/fnsyn.2022.1054605
_version_ 1784851455376621568
author Tang, Chuan
Jin, Ye
Wang, Huan
author_facet Tang, Chuan
Jin, Ye
Wang, Huan
author_sort Tang, Chuan
collection PubMed
description Sepsis-associated encephalopathy (SAE) is a common complication caused by sepsis, and is responsible for increased mortality and poor outcomes in septic patients. Neurological dysfunction is one of the main manifestations of SAE patients. Patients may still have long-term cognitive impairment after hospital discharge, and the underlying mechanism is still unclear. Here, we first outline the pathophysiological changes of SAE, including neuroinflammation, glial activation, and blood-brain barrier (BBB) breakdown. Synapse dysfunction is one of the main contributors leading to neurological impairment. Therefore, we summarized SAE-induced synaptic dysfunction, such as synaptic plasticity inhibition, neurotransmitter imbalance, and synapses loss. Finally, we discuss the alterations in the synapse, synapse formation, and mediators associated with synapse formation during SAE. In this review, we focus on the changes in synapse/synapse formation caused by SAE, which can further understand the synaptic dysfunction associated with neurological impairment in SAE and provide important insights for exploring appropriate therapeutic targets of SAE.
format Online
Article
Text
id pubmed-9755596
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-97555962022-12-17 The biological alterations of synapse/synapse formation in sepsis-associated encephalopathy Tang, Chuan Jin, Ye Wang, Huan Front Synaptic Neurosci Neuroscience Sepsis-associated encephalopathy (SAE) is a common complication caused by sepsis, and is responsible for increased mortality and poor outcomes in septic patients. Neurological dysfunction is one of the main manifestations of SAE patients. Patients may still have long-term cognitive impairment after hospital discharge, and the underlying mechanism is still unclear. Here, we first outline the pathophysiological changes of SAE, including neuroinflammation, glial activation, and blood-brain barrier (BBB) breakdown. Synapse dysfunction is one of the main contributors leading to neurological impairment. Therefore, we summarized SAE-induced synaptic dysfunction, such as synaptic plasticity inhibition, neurotransmitter imbalance, and synapses loss. Finally, we discuss the alterations in the synapse, synapse formation, and mediators associated with synapse formation during SAE. In this review, we focus on the changes in synapse/synapse formation caused by SAE, which can further understand the synaptic dysfunction associated with neurological impairment in SAE and provide important insights for exploring appropriate therapeutic targets of SAE. Frontiers Media S.A. 2022-12-02 /pmc/articles/PMC9755596/ /pubmed/36530954 http://dx.doi.org/10.3389/fnsyn.2022.1054605 Text en Copyright © 2022 Tang, Jin and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Tang, Chuan
Jin, Ye
Wang, Huan
The biological alterations of synapse/synapse formation in sepsis-associated encephalopathy
title The biological alterations of synapse/synapse formation in sepsis-associated encephalopathy
title_full The biological alterations of synapse/synapse formation in sepsis-associated encephalopathy
title_fullStr The biological alterations of synapse/synapse formation in sepsis-associated encephalopathy
title_full_unstemmed The biological alterations of synapse/synapse formation in sepsis-associated encephalopathy
title_short The biological alterations of synapse/synapse formation in sepsis-associated encephalopathy
title_sort biological alterations of synapse/synapse formation in sepsis-associated encephalopathy
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755596/
https://www.ncbi.nlm.nih.gov/pubmed/36530954
http://dx.doi.org/10.3389/fnsyn.2022.1054605
work_keys_str_mv AT tangchuan thebiologicalalterationsofsynapsesynapseformationinsepsisassociatedencephalopathy
AT jinye thebiologicalalterationsofsynapsesynapseformationinsepsisassociatedencephalopathy
AT wanghuan thebiologicalalterationsofsynapsesynapseformationinsepsisassociatedencephalopathy
AT tangchuan biologicalalterationsofsynapsesynapseformationinsepsisassociatedencephalopathy
AT jinye biologicalalterationsofsynapsesynapseformationinsepsisassociatedencephalopathy
AT wanghuan biologicalalterationsofsynapsesynapseformationinsepsisassociatedencephalopathy