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Preliminary evidence for a lower brain age in children with attention-deficit/hyperactivity disorder
Attention-deficit hyperactivity disorder (ADHD) is a debilitating disorder with apparent roots in abnormal brain development. Here, we quantified the level of individual brain maturation in children with ADHD using structural neuroimaging and a recently developed machine learning algorithm. More spe...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755736/ https://www.ncbi.nlm.nih.gov/pubmed/36532197 http://dx.doi.org/10.3389/fpsyt.2022.1019546 |
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author | Kurth, Florian Levitt, Jennifer G. Gaser, Christian Alger, Jeffry Loo, Sandra K. Narr, Katherine L. O’Neill, Joseph Luders, Eileen |
author_facet | Kurth, Florian Levitt, Jennifer G. Gaser, Christian Alger, Jeffry Loo, Sandra K. Narr, Katherine L. O’Neill, Joseph Luders, Eileen |
author_sort | Kurth, Florian |
collection | PubMed |
description | Attention-deficit hyperactivity disorder (ADHD) is a debilitating disorder with apparent roots in abnormal brain development. Here, we quantified the level of individual brain maturation in children with ADHD using structural neuroimaging and a recently developed machine learning algorithm. More specifically, we compared the BrainAGE index between three groups matched for chronological age (mean ± SD: 11.86 ± 3.25 years): 89 children diagnosed with ADHD, 34 asymptomatic siblings of those children with ADHD, and 21 unrelated healthy control children. Brains of children with ADHD were estimated significantly younger (−0.85 years) than brains of healthy controls (Cohen’s d = −0.33; p = 0.028, one-tailed), while there were no significant differences between unaffected siblings and healthy controls. In addition, more severe ADHD symptoms were significantly associated with younger appearing brains. Altogether, these results are in line with the proposed delay of individual brain maturation in children with ADHD. However, given the relatively small sample size (N = 144), the findings should be considered preliminary and need to be confirmed in future studies. |
format | Online Article Text |
id | pubmed-9755736 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97557362022-12-17 Preliminary evidence for a lower brain age in children with attention-deficit/hyperactivity disorder Kurth, Florian Levitt, Jennifer G. Gaser, Christian Alger, Jeffry Loo, Sandra K. Narr, Katherine L. O’Neill, Joseph Luders, Eileen Front Psychiatry Psychiatry Attention-deficit hyperactivity disorder (ADHD) is a debilitating disorder with apparent roots in abnormal brain development. Here, we quantified the level of individual brain maturation in children with ADHD using structural neuroimaging and a recently developed machine learning algorithm. More specifically, we compared the BrainAGE index between three groups matched for chronological age (mean ± SD: 11.86 ± 3.25 years): 89 children diagnosed with ADHD, 34 asymptomatic siblings of those children with ADHD, and 21 unrelated healthy control children. Brains of children with ADHD were estimated significantly younger (−0.85 years) than brains of healthy controls (Cohen’s d = −0.33; p = 0.028, one-tailed), while there were no significant differences between unaffected siblings and healthy controls. In addition, more severe ADHD symptoms were significantly associated with younger appearing brains. Altogether, these results are in line with the proposed delay of individual brain maturation in children with ADHD. However, given the relatively small sample size (N = 144), the findings should be considered preliminary and need to be confirmed in future studies. Frontiers Media S.A. 2022-12-02 /pmc/articles/PMC9755736/ /pubmed/36532197 http://dx.doi.org/10.3389/fpsyt.2022.1019546 Text en Copyright © 2022 Kurth, Levitt, Gaser, Alger, Loo, Narr, O’Neill and Luders. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Psychiatry Kurth, Florian Levitt, Jennifer G. Gaser, Christian Alger, Jeffry Loo, Sandra K. Narr, Katherine L. O’Neill, Joseph Luders, Eileen Preliminary evidence for a lower brain age in children with attention-deficit/hyperactivity disorder |
title | Preliminary evidence for a lower brain age in children with attention-deficit/hyperactivity disorder |
title_full | Preliminary evidence for a lower brain age in children with attention-deficit/hyperactivity disorder |
title_fullStr | Preliminary evidence for a lower brain age in children with attention-deficit/hyperactivity disorder |
title_full_unstemmed | Preliminary evidence for a lower brain age in children with attention-deficit/hyperactivity disorder |
title_short | Preliminary evidence for a lower brain age in children with attention-deficit/hyperactivity disorder |
title_sort | preliminary evidence for a lower brain age in children with attention-deficit/hyperactivity disorder |
topic | Psychiatry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755736/ https://www.ncbi.nlm.nih.gov/pubmed/36532197 http://dx.doi.org/10.3389/fpsyt.2022.1019546 |
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