Leveraging biochemical reactions to unravel functional impacts of cancer somatic variants affecting protein interaction interfaces

Background: Considering protein mutations in their biological context is essential for understanding their functional impact, interpretation of high-dimensional datasets and development of effective targeted therapies in personalized medicine. Methods: We combined the curated knowledge of biochemica...

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Detalles Bibliográficos
Autores principales: Raimondi, Francesco, Burkhart, Joshua G., Betts, Matthew J., Russell, Robert B., Wu, Guanming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755755/
https://www.ncbi.nlm.nih.gov/pubmed/36569594
http://dx.doi.org/10.12688/f1000research.74395.3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755755/
https://www.ncbi.nlm.nih.gov/pubmed/36569594
http://dx.doi.org/10.12688/f1000research.74395.3

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