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Leveraging biochemical reactions to unravel functional impacts of cancer somatic variants affecting protein interaction interfaces
Background: Considering protein mutations in their biological context is essential for understanding their functional impact, interpretation of high-dimensional datasets and development of effective targeted therapies in personalized medicine. Methods: We combined the curated knowledge of biochemica...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
F1000 Research Limited
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755755/ https://www.ncbi.nlm.nih.gov/pubmed/36569594 http://dx.doi.org/10.12688/f1000research.74395.3 |