HDAC5 Loss Enhances Phospholipid-Derived Arachidonic Acid Generation and Confers Sensitivity to cPLA2 Inhibition in Pancreatic Cancer

HDAC5 is a class IIa histone deacetylase member that is downregulated in multiple solid tumors, including pancreatic cancer, and loss of HDAC5 is associated with unfavorable prognosis. In this study, assessment of The Cancer Genome Atlas pancreatic adenocarcinoma dataset revealed that expression of...

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Detalles Bibliográficos
Autores principales: Pan, Penglin, Qin, Gengdu, Wang, Bo, Yu, Haixin, Chen, Jie, Liu, Jiaying, Bing, Kaijian, Shen, Jian, Ren, Dianyun, Zhao, Yuhan, Xia, Wentao, Li, Hui, Wu, Heshui, Zhou, Yingke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Molecular Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755957/
https://www.ncbi.nlm.nih.gov/pubmed/36102738
http://dx.doi.org/10.1158/0008-5472.CAN-21-4362

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755957/
https://www.ncbi.nlm.nih.gov/pubmed/36102738
http://dx.doi.org/10.1158/0008-5472.CAN-21-4362

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