Cargando…

ATM Regulates Differentiation of Myofibroblastic Cancer-Associated Fibroblasts and Can Be Targeted to Overcome Immunotherapy Resistance

Myofibroblastic cancer-associated fibroblast (myoCAF)–rich tumors generally contain few T cells and respond poorly to immune-checkpoint blockade. Although myoCAFs are associated with poor outcome in most solid tumors, the molecular mechanisms regulating myoCAF accumulation remain unclear, limiting t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mellone, Massimiliano, Piotrowska, Klaudia, Venturi, Giulia, James, Lija, Bzura, Aleksandra, Lopez, Maria A., James, Sonya, Wang, Chuan, Ellis, Matthew J., Hanley, Christopher J., Buckingham, Josephine F., Cox, Kerry L., Hughes, Gareth, Valge-Archer, Viia, King, Emma V., Beers, Stephen A., Jaquet, Vincent, Jones, George D.D., Savelyeva, Natalia, Sayan, Emre, Parsons, Jason L., Durant, Stephen, Thomas, Gareth J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Tumor Biology and Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9755965/ https://www.ncbi.nlm.nih.gov/pubmed/36353752 http://dx.doi.org/10.1158/0008-5472.CAN-22-0435

Ejemplares similares

Targeting DNA damage response components induces enhanced STING-dependent type-I IFN response in ATM deficient cancer cells and drives dendritic cell activation
por: Lopez-Pelaez, Marta, et al.
Publicado: (2022)

Inhibition of DNA-PK with AZD7648 Sensitizes Tumor Cells to Radiotherapy and Induces Type I IFN-Dependent Durable Tumor Control
por: Nakamura, Kyoko, et al.
Publicado: (2021)

Targeting the Myofibroblastic Cancer-Associated Fibroblast Phenotype Through Inhibition of NOX4
por: Hanley, Christopher J, et al.
Publicado: (2017)

Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function
por: Cribbs, Adam P., et al.
Publicado: (2021)

Induction of fibroblast senescence generates a non-fibrogenic myofibroblast phenotype that differentially impacts on cancer prognosis
por: Mellone, Massimiliano, et al.
Publicado: (2016)

Age-induced changes in anti-tumor immunity alter the tumor immune infiltrate and impact response to immuno-oncology treatments
por: Sitnikova, Suzanne I., et al.
Publicado: (2023)

A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers
por: Hanley, Christopher J., et al.
Publicado: (2015)

The impact of cellular senescence and DNA damage on colorectal tumour progression
por: Angell, Helen K, et al.
Publicado: (2013)

ATM kinase inhibitor AZD0156 in combination with irinotecan and 5-fluorouracil in preclinical models of colorectal cancer
por: Davis, S. Lindsey, et al.
Publicado: (2022)

ATM-Inhibitor AZD1390 Is a Radiosensitizer for Breast Cancer CNS Metastasis
por: Tew, Ben Yi, et al.
Publicado: (2023)

A cell-engineered system to assess tumor cell sensitivity to CD8(+) T cell-mediated cytotoxicity
por: Nelson, Nadine, et al.
Publicado: (2019)

Targeting Head and Neck Cancer by Vaccination
por: Wang, Chuan, et al.
Publicado: (2018)

MHC class I chain-related protein A and B (MICA and MICB) are predominantly expressed intracellularly in tumour and normal tissue
por: Ghadially, Hormas, et al.
Publicado: (2017)

ATM-Deficient Cancers Provide New Opportunities for Precision Oncology
por: Jette, Nicholas R., et al.
Publicado: (2020)

Epithelial to mesenchymal transition influences fibroblast phenotype in colorectal cancer by altering miR‐200 levels in extracellular vesicles
por: Bhome, Rahul, et al.
Publicado: (2022)

Small Gene Networks Delineate Immune Cell States and Characterize Immunotherapy Response in Melanoma
por: Egan, Donagh, et al.
Publicado: (2023)

ATM research projects
por: Dufey, J P
Publicado: (1996)

Introduction to ATM networking
por: Goralski, Walter J
Publicado: (1995)

CRISPR metabolic screen identifies ATM and KEAP1 as targetable genetic vulnerabilities in solid tumors
por: Li, Haojian, et al.
Publicado: (2023)

Complete loss of ATM function augments replication catastrophe induced by ATR inhibition and gemcitabine in pancreatic cancer models
por: Dunlop, Charles R., et al.
Publicado: (2020)

Atypical ATMs: Broadening the phenotypic spectrum of ATM-associated hereditary cancer
por: Borja, Nicholas A., et al.
Publicado: (2023)

ATM phosphorylates the FATC domain of DNA-PK(cs) at threonine 4102 to promote non-homologous end joining
por: Lu, Huiming, et al.
Publicado: (2023)

T-cell tumour exclusion and immunotherapy resistance: a role for CAF targeting
por: Hanley, Christopher J., et al.
Publicado: (2020)

Targeting cancer associated fibroblasts to enhance immunotherapy: emerging strategies and future perspectives
por: Hanley, Christopher J., et al.
Publicado: (2021)

A high density of tertiary lymphoid structure B cells in lung tumors is associated with increased CD4(+) T cell receptor repertoire clonality
por: Zhu, Wei, et al.
Publicado: (2015)

Cisco voice over frame relay, ATM, and IP
por: Foy, Stephen, et al.
Publicado: (2001)

Metastatic inflammatory myofibroblastic tumor of the bladder
por: Libby, Emma K., et al.
Publicado: (2018)

Reseaux ATM
por: Boisseau, Marc, et al.
Publicado: (1994)

ATM in senescence
por: Aird, Katherine M., et al.
Publicado: (2015)

Inflammatory myofibroblastic tumor of the larynx: Case report
por: Foster, Henry James, et al.
Publicado: (2021)

NADPH oxidase 4 is dispensable for skin myofibroblast differentiation and wound healing
por: Siedlar, Aleksandra Malgorzata, et al.
Publicado: (2023)

PARP inhibition is a modulator of anti-tumor immune response in BRCA-deficient tumors
por: Staniszewska, Anna D., et al.
Publicado: (2022)

ATM: Functions of ATM Kinase and Its Relevance to Hereditary Tumors
por: Ueno, Sayaka, et al.
Publicado: (2022)

PAK proteins and YAP-1 signalling downstream of integrin beta-1 in myofibroblasts promote liver fibrosis
por: Martin, Katherine, et al.
Publicado: (2016)

ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks
por: Balmus, Gabriel, et al.
Publicado: (2019)

Activation of GABA(A) receptors inhibits T cell proliferation
por: Sparrow, Emma L., et al.
Publicado: (2021)

ATM-based Event Building
por: Calvet, D, et al.
Publicado: (1994)

Inhibition of Human Corneal Myofibroblast Formation
por: Guo, Xiaoqing, et al.
Publicado: (2018)

Inflammatory Myofibroblastic Tumor: A Rare Case Report
por: Luke, Nicholas D, et al.
Publicado: (2023)

ATM theory and application
por: McDysan, David E.
Publicado: (1995)

Cannot write session to /tmp/vufind_sessions/sess_ao4n7596nt4aet7k8qpo2g6os7