The effects and mechanism of taxanes on chemotherapy-associated ovarian damage: A review of current evidence

Chemotherapy is often a cause of premature ovarian insufficiency and infertility since the ovarian follicles are extremely sensitive to the effects of chemotherapeutic agents. Different chemotherapeutic agents with varying mechanisms of action may damage ovarian function differently. Taxanes are wid...

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Autores principales: Wu, Chuqing, Wu, Tong, Chen, Dan, Wei, Simin, Tang, Weicheng, Xue, Liru, Xiong, Jiaqiang, Huang, Yibao, Guo, Yican, Chen, Ying, Wu, Meng, Wang, Shixuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9756165/
https://www.ncbi.nlm.nih.gov/pubmed/36531475
http://dx.doi.org/10.3389/fendo.2022.1025018
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author Wu, Chuqing
Wu, Tong
Chen, Dan
Wei, Simin
Tang, Weicheng
Xue, Liru
Xiong, Jiaqiang
Huang, Yibao
Guo, Yican
Chen, Ying
Wu, Meng
Wang, Shixuan
author_facet Wu, Chuqing
Wu, Tong
Chen, Dan
Wei, Simin
Tang, Weicheng
Xue, Liru
Xiong, Jiaqiang
Huang, Yibao
Guo, Yican
Chen, Ying
Wu, Meng
Wang, Shixuan
author_sort Wu, Chuqing
collection PubMed
description Chemotherapy is often a cause of premature ovarian insufficiency and infertility since the ovarian follicles are extremely sensitive to the effects of chemotherapeutic agents. Different chemotherapeutic agents with varying mechanisms of action may damage ovarian function differently. Taxanes are widely used in clinical cancer treatment, but the specific reproductive toxicological information is still controversial. This review described the impact and duration of taxanes on ovarian function in women and analyzed the possible reasons for different conclusions. Furthermore, the toxicity of taxanes on ovarian function and its possible mechanisms were discussed. The potential protective strategies and agents against ovarian damage induced by taxanes are also reviewed.
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spelling pubmed-97561652022-12-17 The effects and mechanism of taxanes on chemotherapy-associated ovarian damage: A review of current evidence Wu, Chuqing Wu, Tong Chen, Dan Wei, Simin Tang, Weicheng Xue, Liru Xiong, Jiaqiang Huang, Yibao Guo, Yican Chen, Ying Wu, Meng Wang, Shixuan Front Endocrinol (Lausanne) Endocrinology Chemotherapy is often a cause of premature ovarian insufficiency and infertility since the ovarian follicles are extremely sensitive to the effects of chemotherapeutic agents. Different chemotherapeutic agents with varying mechanisms of action may damage ovarian function differently. Taxanes are widely used in clinical cancer treatment, but the specific reproductive toxicological information is still controversial. This review described the impact and duration of taxanes on ovarian function in women and analyzed the possible reasons for different conclusions. Furthermore, the toxicity of taxanes on ovarian function and its possible mechanisms were discussed. The potential protective strategies and agents against ovarian damage induced by taxanes are also reviewed. Frontiers Media S.A. 2022-11-24 /pmc/articles/PMC9756165/ /pubmed/36531475 http://dx.doi.org/10.3389/fendo.2022.1025018 Text en Copyright © 2022 Wu, Wu, Chen, Wei, Tang, Xue, Xiong, Huang, Guo, Chen, Wu and Wang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Wu, Chuqing
Wu, Tong
Chen, Dan
Wei, Simin
Tang, Weicheng
Xue, Liru
Xiong, Jiaqiang
Huang, Yibao
Guo, Yican
Chen, Ying
Wu, Meng
Wang, Shixuan
The effects and mechanism of taxanes on chemotherapy-associated ovarian damage: A review of current evidence
title The effects and mechanism of taxanes on chemotherapy-associated ovarian damage: A review of current evidence
title_full The effects and mechanism of taxanes on chemotherapy-associated ovarian damage: A review of current evidence
title_fullStr The effects and mechanism of taxanes on chemotherapy-associated ovarian damage: A review of current evidence
title_full_unstemmed The effects and mechanism of taxanes on chemotherapy-associated ovarian damage: A review of current evidence
title_short The effects and mechanism of taxanes on chemotherapy-associated ovarian damage: A review of current evidence
title_sort effects and mechanism of taxanes on chemotherapy-associated ovarian damage: a review of current evidence
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9756165/
https://www.ncbi.nlm.nih.gov/pubmed/36531475
http://dx.doi.org/10.3389/fendo.2022.1025018
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