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A Novel Indicator of Myocardial Injury after Acute Myocardial Infarction: ‘DPP-3’
BACKGROUND: Dipeptidyl peptidase 3 (DPP-3) is an intracellular enzyme that causes hemodynamic instability and cardiac depression in several cases such as cardiogenic shock, sepsis and burns where DPP-3 is released into the blood due to cell death. Data on the effect of higher DPP-3 levels on acute c...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9756349/ https://www.ncbi.nlm.nih.gov/pubmed/36514254 http://dx.doi.org/10.1177/10760296221145174 |
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author | Ozden, Ozge Yesildas, Cuma Demir, Mustafa Surmeli, Ali Orcun Yesil, Emrah Orscelik, Ozcan Celik, Ahmet |
author_facet | Ozden, Ozge Yesildas, Cuma Demir, Mustafa Surmeli, Ali Orcun Yesil, Emrah Orscelik, Ozcan Celik, Ahmet |
author_sort | Ozden, Ozge |
collection | PubMed |
description | BACKGROUND: Dipeptidyl peptidase 3 (DPP-3) is an intracellular enzyme that causes hemodynamic instability and cardiac depression in several cases such as cardiogenic shock, sepsis and burns where DPP-3 is released into the blood due to cell death. Data on the effect of higher DPP-3 levels on acute coronary syndrome (ACS) patients are currently lacking. The aim of this study was to evaluate the effect of DPP-3 levels on ACS patients. METHODS: In this prospective study, we included ACS patients including STEMI and non-STEMI groups and a control group to compare various demographic, echocardiographic and laboratory parameters including DPP-3. DPP-3 levels were measured at 24(th), 48(th), and 72(nd) h from the onset of symptoms in ACS patients and then compared with left ventricle ejection fraction (LVEF) for the assessment of left ventricle systolic function. RESULTS: A total of 70 ACS patients (age 62.5 ± 11 years, 68.6% male) were recruited and 48 normal individuals were included as control group (age 61.1 ± 10 years, 66.7% male). It has been demonstrated that DPP-3 levels are significantly higher in the ACS group than the control group like troponin I levels. DPP-3 levels were found to be one of the independent predictors of LVEF similar to NT-proBNP and troponin I. CONCLUSIONS: This study suggests that DPP-3 could be an important indicator of myocardial depression predicting left ventricle systolic function in ACS. |
format | Online Article Text |
id | pubmed-9756349 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-97563492022-12-17 A Novel Indicator of Myocardial Injury after Acute Myocardial Infarction: ‘DPP-3’ Ozden, Ozge Yesildas, Cuma Demir, Mustafa Surmeli, Ali Orcun Yesil, Emrah Orscelik, Ozcan Celik, Ahmet Clin Appl Thromb Hemost Original Manuscript BACKGROUND: Dipeptidyl peptidase 3 (DPP-3) is an intracellular enzyme that causes hemodynamic instability and cardiac depression in several cases such as cardiogenic shock, sepsis and burns where DPP-3 is released into the blood due to cell death. Data on the effect of higher DPP-3 levels on acute coronary syndrome (ACS) patients are currently lacking. The aim of this study was to evaluate the effect of DPP-3 levels on ACS patients. METHODS: In this prospective study, we included ACS patients including STEMI and non-STEMI groups and a control group to compare various demographic, echocardiographic and laboratory parameters including DPP-3. DPP-3 levels were measured at 24(th), 48(th), and 72(nd) h from the onset of symptoms in ACS patients and then compared with left ventricle ejection fraction (LVEF) for the assessment of left ventricle systolic function. RESULTS: A total of 70 ACS patients (age 62.5 ± 11 years, 68.6% male) were recruited and 48 normal individuals were included as control group (age 61.1 ± 10 years, 66.7% male). It has been demonstrated that DPP-3 levels are significantly higher in the ACS group than the control group like troponin I levels. DPP-3 levels were found to be one of the independent predictors of LVEF similar to NT-proBNP and troponin I. CONCLUSIONS: This study suggests that DPP-3 could be an important indicator of myocardial depression predicting left ventricle systolic function in ACS. SAGE Publications 2022-12-13 /pmc/articles/PMC9756349/ /pubmed/36514254 http://dx.doi.org/10.1177/10760296221145174 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Manuscript Ozden, Ozge Yesildas, Cuma Demir, Mustafa Surmeli, Ali Orcun Yesil, Emrah Orscelik, Ozcan Celik, Ahmet A Novel Indicator of Myocardial Injury after Acute Myocardial Infarction: ‘DPP-3’ |
title | A Novel Indicator of Myocardial Injury after Acute Myocardial Infarction: ‘DPP-3’ |
title_full | A Novel Indicator of Myocardial Injury after Acute Myocardial Infarction: ‘DPP-3’ |
title_fullStr | A Novel Indicator of Myocardial Injury after Acute Myocardial Infarction: ‘DPP-3’ |
title_full_unstemmed | A Novel Indicator of Myocardial Injury after Acute Myocardial Infarction: ‘DPP-3’ |
title_short | A Novel Indicator of Myocardial Injury after Acute Myocardial Infarction: ‘DPP-3’ |
title_sort | novel indicator of myocardial injury after acute myocardial infarction: ‘dpp-3’ |
topic | Original Manuscript |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9756349/ https://www.ncbi.nlm.nih.gov/pubmed/36514254 http://dx.doi.org/10.1177/10760296221145174 |
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