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Human iPSC-derived neural stem cells with ALDH5A1 mutation as a model of succinic semialdehyde dehydrogenase deficiency

BACKGROUND: Succinic semialdehyde dehydrogenase deficiency (SSADH-D) is an autosomal recessive gamma-aminobutyric acid (GABA) metabolism disorder that can arise due to ALDH5A1 mutations, resulting in severe, progressive, untreatable neurodegeneration. SSADH-D is primarily studied using simplified mo...

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Detalles Bibliográficos
Autores principales:	Chen, Xiaodan, Peng, Minzhi, Cai, Yanna, Zhou, Chengcheng, Liu, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9756581/ https://www.ncbi.nlm.nih.gov/pubmed/36527006 http://dx.doi.org/10.1186/s12868-022-00755-3

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