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Association of polymorphisms in the IL‐10 promoter region with Crohn's disease

BACKGROUND: IL‐10 is thought to play an important role in preventing inflammatory bowel disease (IBD), although its efficacy is limited in IBD inflammation treatment. The purpose of this study is to investigate the association between SNP polymorphism in the promoter region of the IL‐10 gene and Cro...

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Autores principales: Sun, Anna, Li, Wei, Shang, Shiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757008/
https://www.ncbi.nlm.nih.gov/pubmed/36408729
http://dx.doi.org/10.1002/jcla.24780
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author Sun, Anna
Li, Wei
Shang, Shiqiang
author_facet Sun, Anna
Li, Wei
Shang, Shiqiang
author_sort Sun, Anna
collection PubMed
description BACKGROUND: IL‐10 is thought to play an important role in preventing inflammatory bowel disease (IBD), although its efficacy is limited in IBD inflammation treatment. The purpose of this study is to investigate the association between SNP polymorphism in the promoter region of the IL‐10 gene and Crohn's disease (CD). METHODS: In 86 children with CD disease and 142 healthy controls, polymorphisms of three SNPs (rs3790622, rs1800872, and rs1800896) in the IL‐10 promoter region were successfully identified. The risk alleles, genotypes, and haplotypes were also analyzed in the CD patient group and the control group. 2 × 2 chi‐square test was used to identify whether there is a statistically significant association between CD risk and SNP polymorphisms. RESULTS: According to the chi‐square test results, only the polymorphism of rs1800872 was associated with pediatric CD. T allele in rs1800872 showed a high risk for pediatric CD (Pearson χ (2) p = 0.030). TT genotype of rs1800872 was associated with a higher risk of CD in the pediatric population (OR 1.986, 95% CI 1.146–3.442, p = 0.020, TT vs. TG + GG). Finally, a risk haplotype GTT (rs3790622‐rs1800872‐rs1800896) in IL‐10 was found (OR 1.570, 95% CI 1.054–2.341, p = 0.028). CONCLUSIONS: Our data suggested that T allele, TT genotype, and haplotype GTT in rs1800872 were associated with the susceptibility to pediatric CD in China.
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spelling pubmed-97570082022-12-20 Association of polymorphisms in the IL‐10 promoter region with Crohn's disease Sun, Anna Li, Wei Shang, Shiqiang J Clin Lab Anal Research Articles BACKGROUND: IL‐10 is thought to play an important role in preventing inflammatory bowel disease (IBD), although its efficacy is limited in IBD inflammation treatment. The purpose of this study is to investigate the association between SNP polymorphism in the promoter region of the IL‐10 gene and Crohn's disease (CD). METHODS: In 86 children with CD disease and 142 healthy controls, polymorphisms of three SNPs (rs3790622, rs1800872, and rs1800896) in the IL‐10 promoter region were successfully identified. The risk alleles, genotypes, and haplotypes were also analyzed in the CD patient group and the control group. 2 × 2 chi‐square test was used to identify whether there is a statistically significant association between CD risk and SNP polymorphisms. RESULTS: According to the chi‐square test results, only the polymorphism of rs1800872 was associated with pediatric CD. T allele in rs1800872 showed a high risk for pediatric CD (Pearson χ (2) p = 0.030). TT genotype of rs1800872 was associated with a higher risk of CD in the pediatric population (OR 1.986, 95% CI 1.146–3.442, p = 0.020, TT vs. TG + GG). Finally, a risk haplotype GTT (rs3790622‐rs1800872‐rs1800896) in IL‐10 was found (OR 1.570, 95% CI 1.054–2.341, p = 0.028). CONCLUSIONS: Our data suggested that T allele, TT genotype, and haplotype GTT in rs1800872 were associated with the susceptibility to pediatric CD in China. John Wiley and Sons Inc. 2022-11-21 /pmc/articles/PMC9757008/ /pubmed/36408729 http://dx.doi.org/10.1002/jcla.24780 Text en © 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Research Articles
Sun, Anna
Li, Wei
Shang, Shiqiang
Association of polymorphisms in the IL‐10 promoter region with Crohn's disease
title Association of polymorphisms in the IL‐10 promoter region with Crohn's disease
title_full Association of polymorphisms in the IL‐10 promoter region with Crohn's disease
title_fullStr Association of polymorphisms in the IL‐10 promoter region with Crohn's disease
title_full_unstemmed Association of polymorphisms in the IL‐10 promoter region with Crohn's disease
title_short Association of polymorphisms in the IL‐10 promoter region with Crohn's disease
title_sort association of polymorphisms in the il‐10 promoter region with crohn's disease
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757008/
https://www.ncbi.nlm.nih.gov/pubmed/36408729
http://dx.doi.org/10.1002/jcla.24780
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