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Giant plasma cells with multiple immature nuclei in a young woman with newly diagnosed multiple myeloma
BACKGROUND: Multiple myeloma with giant multinucleated plasma cells is a very rare entity and mostly reported cases are dated. This plasma cell morphology has been observed after monoclonal antibody treatments, such as daratumumab, and patients have experienced a worse prognosis with partial respons...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757013/ https://www.ncbi.nlm.nih.gov/pubmed/36397299 http://dx.doi.org/10.1002/jcla.24782 |
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author | Giudice, Valentina De Novellis, Danilo Guariglia, Roberto Fumo, Rosalba Ciancia, Giuseppe Serio, Bianca Selleri, Carmine |
author_facet | Giudice, Valentina De Novellis, Danilo Guariglia, Roberto Fumo, Rosalba Ciancia, Giuseppe Serio, Bianca Selleri, Carmine |
author_sort | Giudice, Valentina |
collection | PubMed |
description | BACKGROUND: Multiple myeloma with giant multinucleated plasma cells is a very rare entity and mostly reported cases are dated. This plasma cell morphology has been observed after monoclonal antibody treatments, such as daratumumab, and patients have experienced a worse prognosis with partial responses and a high rate of relapse. RESULTS: Here, we showed a newly diagnosed multiple myeloma with giant plasma cells with multiple (up to 13) immature nuclei who achieved a complete remission after a first line therapy and underwent to autologous hematopoietic stem cell transplantation, as per international guidelines. |
format | Online Article Text |
id | pubmed-9757013 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-97570132022-12-20 Giant plasma cells with multiple immature nuclei in a young woman with newly diagnosed multiple myeloma Giudice, Valentina De Novellis, Danilo Guariglia, Roberto Fumo, Rosalba Ciancia, Giuseppe Serio, Bianca Selleri, Carmine J Clin Lab Anal Case Report BACKGROUND: Multiple myeloma with giant multinucleated plasma cells is a very rare entity and mostly reported cases are dated. This plasma cell morphology has been observed after monoclonal antibody treatments, such as daratumumab, and patients have experienced a worse prognosis with partial responses and a high rate of relapse. RESULTS: Here, we showed a newly diagnosed multiple myeloma with giant plasma cells with multiple (up to 13) immature nuclei who achieved a complete remission after a first line therapy and underwent to autologous hematopoietic stem cell transplantation, as per international guidelines. John Wiley and Sons Inc. 2022-11-17 /pmc/articles/PMC9757013/ /pubmed/36397299 http://dx.doi.org/10.1002/jcla.24782 Text en © 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Giudice, Valentina De Novellis, Danilo Guariglia, Roberto Fumo, Rosalba Ciancia, Giuseppe Serio, Bianca Selleri, Carmine Giant plasma cells with multiple immature nuclei in a young woman with newly diagnosed multiple myeloma |
title | Giant plasma cells with multiple immature nuclei in a young woman with newly diagnosed multiple myeloma |
title_full | Giant plasma cells with multiple immature nuclei in a young woman with newly diagnosed multiple myeloma |
title_fullStr | Giant plasma cells with multiple immature nuclei in a young woman with newly diagnosed multiple myeloma |
title_full_unstemmed | Giant plasma cells with multiple immature nuclei in a young woman with newly diagnosed multiple myeloma |
title_short | Giant plasma cells with multiple immature nuclei in a young woman with newly diagnosed multiple myeloma |
title_sort | giant plasma cells with multiple immature nuclei in a young woman with newly diagnosed multiple myeloma |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757013/ https://www.ncbi.nlm.nih.gov/pubmed/36397299 http://dx.doi.org/10.1002/jcla.24782 |
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