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Giant plasma cells with multiple immature nuclei in a young woman with newly diagnosed multiple myeloma

BACKGROUND: Multiple myeloma with giant multinucleated plasma cells is a very rare entity and mostly reported cases are dated. This plasma cell morphology has been observed after monoclonal antibody treatments, such as daratumumab, and patients have experienced a worse prognosis with partial respons...

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Autores principales: Giudice, Valentina, De Novellis, Danilo, Guariglia, Roberto, Fumo, Rosalba, Ciancia, Giuseppe, Serio, Bianca, Selleri, Carmine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757013/
https://www.ncbi.nlm.nih.gov/pubmed/36397299
http://dx.doi.org/10.1002/jcla.24782
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author Giudice, Valentina
De Novellis, Danilo
Guariglia, Roberto
Fumo, Rosalba
Ciancia, Giuseppe
Serio, Bianca
Selleri, Carmine
author_facet Giudice, Valentina
De Novellis, Danilo
Guariglia, Roberto
Fumo, Rosalba
Ciancia, Giuseppe
Serio, Bianca
Selleri, Carmine
author_sort Giudice, Valentina
collection PubMed
description BACKGROUND: Multiple myeloma with giant multinucleated plasma cells is a very rare entity and mostly reported cases are dated. This plasma cell morphology has been observed after monoclonal antibody treatments, such as daratumumab, and patients have experienced a worse prognosis with partial responses and a high rate of relapse. RESULTS: Here, we showed a newly diagnosed multiple myeloma with giant plasma cells with multiple (up to 13) immature nuclei who achieved a complete remission after a first line therapy and underwent to autologous hematopoietic stem cell transplantation, as per international guidelines.
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spelling pubmed-97570132022-12-20 Giant plasma cells with multiple immature nuclei in a young woman with newly diagnosed multiple myeloma Giudice, Valentina De Novellis, Danilo Guariglia, Roberto Fumo, Rosalba Ciancia, Giuseppe Serio, Bianca Selleri, Carmine J Clin Lab Anal Case Report BACKGROUND: Multiple myeloma with giant multinucleated plasma cells is a very rare entity and mostly reported cases are dated. This plasma cell morphology has been observed after monoclonal antibody treatments, such as daratumumab, and patients have experienced a worse prognosis with partial responses and a high rate of relapse. RESULTS: Here, we showed a newly diagnosed multiple myeloma with giant plasma cells with multiple (up to 13) immature nuclei who achieved a complete remission after a first line therapy and underwent to autologous hematopoietic stem cell transplantation, as per international guidelines. John Wiley and Sons Inc. 2022-11-17 /pmc/articles/PMC9757013/ /pubmed/36397299 http://dx.doi.org/10.1002/jcla.24782 Text en © 2022 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Giudice, Valentina
De Novellis, Danilo
Guariglia, Roberto
Fumo, Rosalba
Ciancia, Giuseppe
Serio, Bianca
Selleri, Carmine
Giant plasma cells with multiple immature nuclei in a young woman with newly diagnosed multiple myeloma
title Giant plasma cells with multiple immature nuclei in a young woman with newly diagnosed multiple myeloma
title_full Giant plasma cells with multiple immature nuclei in a young woman with newly diagnosed multiple myeloma
title_fullStr Giant plasma cells with multiple immature nuclei in a young woman with newly diagnosed multiple myeloma
title_full_unstemmed Giant plasma cells with multiple immature nuclei in a young woman with newly diagnosed multiple myeloma
title_short Giant plasma cells with multiple immature nuclei in a young woman with newly diagnosed multiple myeloma
title_sort giant plasma cells with multiple immature nuclei in a young woman with newly diagnosed multiple myeloma
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757013/
https://www.ncbi.nlm.nih.gov/pubmed/36397299
http://dx.doi.org/10.1002/jcla.24782
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