5-Methyl-cytosine stabilizes DNA but hinders DNA hybridization revealed by magnetic tweezers and simulations

5-Methyl-cytosine (5mC) is one of the most important DNA modifications and plays versatile biological roles. It is well known that 5mC stabilizes DNA duplexes. However, it remains unclear how 5mC affects the kinetics of DNA melting and hybridization. Here, we studied the kinetics of unzipping and re...

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Detalles Bibliográficos
Autores principales: Zhao, Xiao-Cong, Dong, Hai-Long, Li, Xiao-Lu, Yang, Hong-Yu, Chen, Xue-Feng, Dai, Liang, Wu, Wen-Qiang, Tan, Zhi-Jie, Zhang, Xing-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757033/
https://www.ncbi.nlm.nih.gov/pubmed/36477372
http://dx.doi.org/10.1093/nar/gkac1122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757033/
https://www.ncbi.nlm.nih.gov/pubmed/36477372
http://dx.doi.org/10.1093/nar/gkac1122

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