Human DNA polymerase α has a strong mutagenic potential at the initial steps of DNA synthesis

DNA polymerase α (Polα) is essential for DNA replication initiation and makes a notable contribution to genome mutagenesis. The activity and fidelity of Polα during the early steps of DNA replication have not been well studied. Here we show that at the beginning of DNA synthesis, when extending the...

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Detalles Bibliográficos
Autores principales: Lisova, Alisa E, Baranovskiy, Andrey G, Morstadt, Lucia M, Babayeva, Nigar D, Tahirov, Tahir H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757036/
https://www.ncbi.nlm.nih.gov/pubmed/36454017
http://dx.doi.org/10.1093/nar/gkac1101

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