Cargando…

Spontaneous binding of single-stranded RNAs to RRM proteins visualized by unbiased atomistic simulations with a rescaled RNA force field

Recognition of single-stranded RNA (ssRNA) by RNA recognition motif (RRM) domains is an important class of protein–RNA interactions. Many such complexes were characterized using nuclear magnetic resonance (NMR) and/or X-ray crystallography techniques, revealing ensemble-averaged pictures of the boun...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krepl, Miroslav, Pokorná, Pavlína, Mlýnský, Vojtěch, Stadlbauer, Petr, Šponer, Jiří
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	RNA and RNA-protein complexes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757038/ https://www.ncbi.nlm.nih.gov/pubmed/36454011 http://dx.doi.org/10.1093/nar/gkac1106

Ejemplares similares

Complexity of Guanine Quadruplex Unfolding Pathways Revealed by Atomistic Pulling Simulations
por: Stadlbauer, Petr, et al.
Publicado: (2023)

Spliceosomal SL1 RNA binding to U1-70K: the role of the extended RRM
por: Gopan, Gopika, et al.
Publicado: (2022)

Double-stranded RNA bending by AU-tract sequences
por: Marin-Gonzalez, Alberto, et al.
Publicado: (2020)

Asymmetrical effects of deafness-associated mitochondrial DNA 7516delA mutation on the processing of RNAs in the H-strand and L-strand polycistronic transcripts
por: Xiao, Yun, et al.
Publicado: (2020)

Hidden sequence specificity in loading of single-stranded RNAs onto Drosophila Argonautes
por: Goh, Eling, et al.
Publicado: (2019)

Structural basis of chimpanzee APOBEC3H dimerization stabilized by double-stranded RNA
por: Matsuoka, Tatsuya, et al.
Publicado: (2018)

Tuning strand displacement kinetics enables programmable ZTP riboswitch dynamic range in vivo
por: Bushhouse, David Z, et al.
Publicado: (2023)

Dengue virus 2 capsid protein chaperones the strand displacement of 5′-3′ cyclization sequences
por: Yong, Xin Ee, et al.
Publicado: (2021)

A multidisciplinary approach to the identification of the protein–RNA connectome in double-stranded RNA virus capsids
por: Sung, Po-yu, et al.
Publicado: (2023)

Compositional complementarity between genomic RNA and coat proteins in positive-sense single-stranded RNA viruses
por: Adlhart, Marlene, et al.
Publicado: (2022)

Molecular basis for transfer RNA recognition by the double-stranded RNA-binding domain of human dihydrouridine synthase 2
por: Bou-Nader, Charles, et al.
Publicado: (2019)

A ribonuclease III involved in virulence of Mucorales fungi has evolved to cut exclusively single-stranded RNA
por: Cánovas-Márquez, José Tomás, et al.
Publicado: (2021)

Double-stranded RNA drives SARS-CoV-2 nucleocapsid protein to undergo phase separation at specific temperatures
por: Roden, Christine A, et al.
Publicado: (2022)

The double-stranded RNA-binding protein, Staufen1, is an IRES-transacting factor regulating HIV-1 cap-independent translation initiation
por: Ramos, Hade, et al.
Publicado: (2021)

N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing
por: Bartosovic, Marek, et al.
Publicado: (2017)

Unfolding of an RNA G-quadruplex motif in the negative strand genome of porcine reproductive and respiratory syndrome virus by host and viral helicases to promote viral replication
por: Fang, Puxian, et al.
Publicado: (2023)

MicroRNA dilution during oocyte growth disables the microRNA pathway in mammalian oocytes
por: Kataruka, Shubhangini, et al.
Publicado: (2020)

Hypertension-associated mitochondrial DNA 4401A>G mutation caused the aberrant processing of tRNA(Met), all 8 tRNAs and ND6 mRNA in the light-strand transcript
por: Zhao, Xiaoxu, et al.
Publicado: (2019)

Evolution of plant telomerase RNAs: farther to the past, deeper to the roots
por: Fajkus, Petr, et al.
Publicado: (2021)

Telomerase RNAs in land plants
por: Fajkus, Petr, et al.
Publicado: (2019)

Telomerase RNA in Hymenoptera (Insecta) switched to plant/ciliate-like biogenesis
por: Fajkus, Petr, et al.
Publicado: (2022)

Rescue of spinal muscular atrophy mouse models with AAV9-Exon-specific U1 snRNA
por: Donadon, Irving, et al.
Publicado: (2019)

The most abundant maternal lncRNA Sirena1 acts post-transcriptionally and impacts mitochondrial distribution
por: Ganesh, Sravya, et al.
Publicado: (2020)

METTL15 interacts with the assembly intermediate of murine mitochondrial small ribosomal subunit to form m(4)C840 12S rRNA residue
por: Laptev, Ivan, et al.
Publicado: (2020)

Integrator subunit 4 is a ‘Symplekin-like’ scaffold that associates with INTS9/11 to form the Integrator cleavage module
por: Albrecht, Todd R, et al.
Publicado: (2018)

A role for the Saccharomyces cerevisiae ABCF protein New1 in translation termination/recycling
por: Kasari, Villu, et al.
Publicado: (2019)

Mechanism of translation inhibition by type II GNAT toxin AtaT2
por: Ovchinnikov, Stepan V, et al.
Publicado: (2020)

Translation at first sight: the influence of leading codons
por: Osterman, Ilya A, et al.
Publicado: (2020)

A mechanism underlying position-specific regulation of alternative splicing
por: Hamid, Fursham M., et al.
Publicado: (2017)

A cautionary tale of sense-antisense gene pairs: independent regulation despite inverse correlation of expression
por: Goyal, Ashish, et al.
Publicado: (2017)

Nol12 is a multifunctional RNA binding protein at the nexus of RNA and DNA metabolism
por: Scott, Daniel D., et al.
Publicado: (2017)

The RNA binding protein EWS is broadly involved in the regulation of pri-miRNA processing in mammalian cells
por: Ouyang, Huiwu, et al.
Publicado: (2017)

The MRPP1/MRPP2 complex is a tRNA-maturation platform in human mitochondria
por: Reinhard, Linda, et al.
Publicado: (2017)

Novel mechanisms of eIF2B action and regulation by eIF2α phosphorylation
por: Bogorad, Andrew M., et al.
Publicado: (2017)

Competition between translation initiation factor eIF5 and its mimic protein 5MP determines non-AUG initiation rate genome-wide
por: Tang, Leiming, et al.
Publicado: (2017)

Cdk5rap1-mediated 2-methylthio-N(6)-isopentenyladenosine modification is absent from nuclear-derived RNA species
por: Fakruddin, Md., et al.
Publicado: (2017)

The SMAD3 transcription factor binds complex RNA structures with high affinity
por: Dickey, Thayne H., et al.
Publicado: (2017)

An engineered RNA binding protein with improved splicing regulation
por: Hale, Melissa A, et al.
Publicado: (2018)

Cold-inducible RNA-binding protein (CIRP) induces translation of the cell-cycle inhibitor p27(Kip1)
por: Roilo, Martina, et al.
Publicado: (2018)

Viewing pre-60S maturation at a minute’s timescale
por: Zisser, Gertrude, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_bmu2itrjamt3i3ohfggad61use