TGS1 impacts snRNA 3′-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration

Trimethylguanosine synthase 1 (TGS1) is a highly conserved enzyme that converts the 5′-monomethylguanosine cap of small nuclear RNAs (snRNAs) to a trimethylguanosine cap. Here, we show that loss of TGS1 in Caenorhabditis elegans, Drosophila melanogaster and Danio rerio results in neurological phenot...

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Autores principales: Chen, Lu, Roake, Caitlin M, Maccallini, Paolo, Bavasso, Francesca, Dehghannasiri, Roozbeh, Santonicola, Pamela, Mendoza-Ferreira, Natalia, Scatolini, Livia, Rizzuti, Ludovico, Esposito, Alessandro, Gallotta, Ivan, Francia, Sofia, Cacchione, Stefano, Galati, Alessandra, Palumbo, Valeria, Kobin, Marie A, Tartaglia, Gian Gaetano, Colantoni, Alessio, Proietti, Gabriele, Wu, Yunming, Hammerschmidt, Matthias, De Pittà, Cristiano, Sales, Gabriele, Salzman, Julia, Pellizzoni, Livio, Wirth, Brunhilde, Di Schiavi, Elia, Gatti, Maurizio, Artandi, Steven E, Raffa, Grazia D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757054/
https://www.ncbi.nlm.nih.gov/pubmed/35947650
http://dx.doi.org/10.1093/nar/gkac659

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