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Simultaneous editing of TCR, HLA-I/II and HLA-E resulted in enhanced universal CAR-T resistance to allo-rejection

INTRODUCTION: The major challenge for universal chimeric antigen receptor T cell (UCAR-T) therapy is the inability to persist for a long time in patients leading to inferior efficacy clinically. The objective of this study was to design a novel UCAR-T cell that could avoid the occurrence of allo-rej...

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Detalles Bibliográficos
Autores principales:	Li, Wuling, Zhu, Xiuxiu, Xu, Yanmin, Chen, Jun, Zhang, Hongtao, Yang, Zhi, Qi, Yanan, Hong, Juan, Li, Yunyan, Wang, Guixue, Shen, Junjie, Qian, Cheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757162/ https://www.ncbi.nlm.nih.gov/pubmed/36532006 http://dx.doi.org/10.3389/fimmu.2022.1052717

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