Cellular senescence enhances adaptive anticancer immunosurveillance

Cancer therapy often induces senescence in some cancer cells. Senescent cells, due to their profoundly altered biology, may conceivably interact with the adaptive immune system in novel ways that may boost cancer immunosurveillance, triggering the clearance of both senescent and non-senescent neopla...

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Detalles Bibliográficos
Autores principales: Marin, Ines, Serrano, Manuel, Pietrocola, Federico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Author’s View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757484/
https://www.ncbi.nlm.nih.gov/pubmed/36531690
http://dx.doi.org/10.1080/2162402X.2022.2154115
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author Marin, Ines
Serrano, Manuel
Pietrocola, Federico
author_facet Marin, Ines
Serrano, Manuel
Pietrocola, Federico
author_sort Marin, Ines
collection PubMed
description Cancer therapy often induces senescence in some cancer cells. Senescent cells, due to their profoundly altered biology, may conceivably interact with the adaptive immune system in novel ways that may boost cancer immunosurveillance, triggering the clearance of both senescent and non-senescent neoplastic cells. In this regard, we have recently reported that senescent cancer cells exhibit potent antigenicity and adjuvanticity and can elicit strong CD8(+) T cell-dependent anticancer effects when used as vaccination agents.
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spelling pubmed-97574842022-12-17 Cellular senescence enhances adaptive anticancer immunosurveillance Marin, Ines Serrano, Manuel Pietrocola, Federico Oncoimmunology Author’s View Cancer therapy often induces senescence in some cancer cells. Senescent cells, due to their profoundly altered biology, may conceivably interact with the adaptive immune system in novel ways that may boost cancer immunosurveillance, triggering the clearance of both senescent and non-senescent neoplastic cells. In this regard, we have recently reported that senescent cancer cells exhibit potent antigenicity and adjuvanticity and can elicit strong CD8(+) T cell-dependent anticancer effects when used as vaccination agents. Taylor & Francis 2022-12-15 /pmc/articles/PMC9757484/ /pubmed/36531690 http://dx.doi.org/10.1080/2162402X.2022.2154115 Text en © 2022 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author’s View
Marin, Ines
Serrano, Manuel
Pietrocola, Federico
Cellular senescence enhances adaptive anticancer immunosurveillance
title Cellular senescence enhances adaptive anticancer immunosurveillance
title_full Cellular senescence enhances adaptive anticancer immunosurveillance
title_fullStr Cellular senescence enhances adaptive anticancer immunosurveillance
title_full_unstemmed Cellular senescence enhances adaptive anticancer immunosurveillance
title_short Cellular senescence enhances adaptive anticancer immunosurveillance
title_sort cellular senescence enhances adaptive anticancer immunosurveillance
topic Author’s View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757484/
https://www.ncbi.nlm.nih.gov/pubmed/36531690
http://dx.doi.org/10.1080/2162402X.2022.2154115
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