Intracavitary adoptive transfer of IL-12 mRNA-engineered tumor-specific CD8(+) T cells eradicates peritoneal metastases in mouse models

Previous studies have shown that local delivery of tumor antigen-specific CD8(+) T lymphocytes engineered to transiently express single-chain IL-12 mRNA is highly efficacious. Peritoneal dissemination of cancer is a frequent and often fatal patient condition usually diagnosed when the tumor burden i...

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Detalles Bibliográficos
Autores principales: Di Trani, Claudia Augusta, Cirella, Assunta, Arrizabalaga, Leire, Bella, Ángela, Fernandez-Sendin, Myriam, Russo-Cabrera, Joan Salvador, Gomar, Celia, Olivera, Irene, Bolaños, Elizabeth, González-Gomariz, José, Álvarez, Maite, Etxeberria, Iñaki, Palencia, Belen, Teijeira, Álvaro, Melero, Ignacio, Berraondo, Pedro, Aranda, Fernando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757485/
https://www.ncbi.nlm.nih.gov/pubmed/36531687
http://dx.doi.org/10.1080/2162402X.2022.2147317

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