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Isolated Neuropsychiatric Features with Non-functioning Pituitary Adenoma: Association or Coincidence?

Non-functioning pituitary macroadenomas are often detected after a long latency period, with symptoms due to compression of adjacent structures (headache, visual field abnormality) and hyposecretion of pituitary hormones. Irrespective of endocrinal disturbances, these patients sometimes demonstrate...

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Detalles Bibliográficos
Autores principales: Sharawat, Indar Kumar, Panda, Prateek Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757504/
https://www.ncbi.nlm.nih.gov/pubmed/36531765
http://dx.doi.org/10.4103/jpn.JPN_197_20
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author Sharawat, Indar Kumar
Panda, Prateek Kumar
author_facet Sharawat, Indar Kumar
Panda, Prateek Kumar
author_sort Sharawat, Indar Kumar
collection PubMed
description Non-functioning pituitary macroadenomas are often detected after a long latency period, with symptoms due to compression of adjacent structures (headache, visual field abnormality) and hyposecretion of pituitary hormones. Irrespective of endocrinal disturbances, these patients sometimes demonstrate mood abnormalities, cognitive deterioration, and psychotic symptoms, in such cases usually other symptoms prevail in the clinical picture. Only rare anecdotal case reports are available in which isolated neuropsychiatric or cognitive symptoms were the presenting features of pituitary adenomas. We report a 17-year-old boy with non-functioning pituitary macroadenoma, who presented with depressive symptoms for 6 months, along with predominantly mood-congruent psychotic features and anterograde memory impairment. On subsequent evaluation, he was found to have subclinical abnormalities in visual field testing. His endocrinological and other ancillary investigations were normal. He partially responded to multiple antidepressants and is currently being planned for surgical intervention. Hence, clinicians need to perform neuroimaging in cases with depressive symptoms, when the course is atypical, unsatisfactory response to multiple antidepressants, prominent psychotic/memory-related symptoms to rule out secondary causes. In such cases, pituitary adenomas should also be considered as one of the clinical differentials.
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spelling pubmed-97575042022-12-17 Isolated Neuropsychiatric Features with Non-functioning Pituitary Adenoma: Association or Coincidence? Sharawat, Indar Kumar Panda, Prateek Kumar J Pediatr Neurosci Case Reports Non-functioning pituitary macroadenomas are often detected after a long latency period, with symptoms due to compression of adjacent structures (headache, visual field abnormality) and hyposecretion of pituitary hormones. Irrespective of endocrinal disturbances, these patients sometimes demonstrate mood abnormalities, cognitive deterioration, and psychotic symptoms, in such cases usually other symptoms prevail in the clinical picture. Only rare anecdotal case reports are available in which isolated neuropsychiatric or cognitive symptoms were the presenting features of pituitary adenomas. We report a 17-year-old boy with non-functioning pituitary macroadenoma, who presented with depressive symptoms for 6 months, along with predominantly mood-congruent psychotic features and anterograde memory impairment. On subsequent evaluation, he was found to have subclinical abnormalities in visual field testing. His endocrinological and other ancillary investigations were normal. He partially responded to multiple antidepressants and is currently being planned for surgical intervention. Hence, clinicians need to perform neuroimaging in cases with depressive symptoms, when the course is atypical, unsatisfactory response to multiple antidepressants, prominent psychotic/memory-related symptoms to rule out secondary causes. In such cases, pituitary adenomas should also be considered as one of the clinical differentials. Wolters Kluwer - Medknow 2021 2021-07-19 /pmc/articles/PMC9757504/ /pubmed/36531765 http://dx.doi.org/10.4103/jpn.JPN_197_20 Text en Copyright: © 2021 Journal of Pediatric Neurosciences https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Reports
Sharawat, Indar Kumar
Panda, Prateek Kumar
Isolated Neuropsychiatric Features with Non-functioning Pituitary Adenoma: Association or Coincidence?
title Isolated Neuropsychiatric Features with Non-functioning Pituitary Adenoma: Association or Coincidence?
title_full Isolated Neuropsychiatric Features with Non-functioning Pituitary Adenoma: Association or Coincidence?
title_fullStr Isolated Neuropsychiatric Features with Non-functioning Pituitary Adenoma: Association or Coincidence?
title_full_unstemmed Isolated Neuropsychiatric Features with Non-functioning Pituitary Adenoma: Association or Coincidence?
title_short Isolated Neuropsychiatric Features with Non-functioning Pituitary Adenoma: Association or Coincidence?
title_sort isolated neuropsychiatric features with non-functioning pituitary adenoma: association or coincidence?
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757504/
https://www.ncbi.nlm.nih.gov/pubmed/36531765
http://dx.doi.org/10.4103/jpn.JPN_197_20
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