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Two Unusual Cases of Pituitary Tumors Presenting with Pediatric Acromegaly

Gigantism and acromegaly are most commonly caused by a growth hormone (GH)-secreting pituitary adenoma. Pediatric cases are diagnostically and therapeutically challenging due to their insidious nature. This article presents two adolescent females who were referred to the endocrinology clinic primari...

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Autores principales: Gurnurkar, Shilpa, Patel, Unnati, Seekford, Jennifer, Carakushansky, Mauri, Chegondi, Madhuradhar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757648/
https://www.ncbi.nlm.nih.gov/pubmed/36540490
http://dx.doi.org/10.7759/cureus.31604
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author Gurnurkar, Shilpa
Patel, Unnati
Seekford, Jennifer
Carakushansky, Mauri
Chegondi, Madhuradhar
author_facet Gurnurkar, Shilpa
Patel, Unnati
Seekford, Jennifer
Carakushansky, Mauri
Chegondi, Madhuradhar
author_sort Gurnurkar, Shilpa
collection PubMed
description Gigantism and acromegaly are most commonly caused by a growth hormone (GH)-secreting pituitary adenoma. Pediatric cases are diagnostically and therapeutically challenging due to their insidious nature. This article presents two adolescent females who were referred to the endocrinology clinic primarily for the evaluation of menstrual disorders rather than for concerns about GH excess. Patient one was a 16-year-old who presented with primary amenorrhea and tall stature, and patient two, a 15-year-old, presented with a history of irregular menstruation. Both patients were noted to have acromegalic features, and an extensive work-up confirmed GH-secreting pituitary adenomas. In addition, patient two had significant hyperprolactinemia. Transsphenoidal tumor resection was performed on both patients; patient one had a successful complete resection and achieved endocrine remission, while patient two underwent partial resection followed by a short clinical trial of pegvisomant without significant success. Improved clinical knowledge through case reports can assist with the early diagnosis and management of such rare pediatric conditions.
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spelling pubmed-97576482022-12-19 Two Unusual Cases of Pituitary Tumors Presenting with Pediatric Acromegaly Gurnurkar, Shilpa Patel, Unnati Seekford, Jennifer Carakushansky, Mauri Chegondi, Madhuradhar Cureus Endocrinology/Diabetes/Metabolism Gigantism and acromegaly are most commonly caused by a growth hormone (GH)-secreting pituitary adenoma. Pediatric cases are diagnostically and therapeutically challenging due to their insidious nature. This article presents two adolescent females who were referred to the endocrinology clinic primarily for the evaluation of menstrual disorders rather than for concerns about GH excess. Patient one was a 16-year-old who presented with primary amenorrhea and tall stature, and patient two, a 15-year-old, presented with a history of irregular menstruation. Both patients were noted to have acromegalic features, and an extensive work-up confirmed GH-secreting pituitary adenomas. In addition, patient two had significant hyperprolactinemia. Transsphenoidal tumor resection was performed on both patients; patient one had a successful complete resection and achieved endocrine remission, while patient two underwent partial resection followed by a short clinical trial of pegvisomant without significant success. Improved clinical knowledge through case reports can assist with the early diagnosis and management of such rare pediatric conditions. Cureus 2022-11-17 /pmc/articles/PMC9757648/ /pubmed/36540490 http://dx.doi.org/10.7759/cureus.31604 Text en Copyright © 2022, Gurnurkar et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Endocrinology/Diabetes/Metabolism
Gurnurkar, Shilpa
Patel, Unnati
Seekford, Jennifer
Carakushansky, Mauri
Chegondi, Madhuradhar
Two Unusual Cases of Pituitary Tumors Presenting with Pediatric Acromegaly
title Two Unusual Cases of Pituitary Tumors Presenting with Pediatric Acromegaly
title_full Two Unusual Cases of Pituitary Tumors Presenting with Pediatric Acromegaly
title_fullStr Two Unusual Cases of Pituitary Tumors Presenting with Pediatric Acromegaly
title_full_unstemmed Two Unusual Cases of Pituitary Tumors Presenting with Pediatric Acromegaly
title_short Two Unusual Cases of Pituitary Tumors Presenting with Pediatric Acromegaly
title_sort two unusual cases of pituitary tumors presenting with pediatric acromegaly
topic Endocrinology/Diabetes/Metabolism
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757648/
https://www.ncbi.nlm.nih.gov/pubmed/36540490
http://dx.doi.org/10.7759/cureus.31604
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