In vivo characterization of glutamine metabolism identifies therapeutic targets in clear cell renal cell carcinoma

Targeting metabolic vulnerabilities has been proposed as a therapeutic strategy in renal cell carcinoma (RCC). Here, we analyzed the metabolism of patient-derived xenografts (tumorgrafts) from diverse subtypes of RCC. Tumorgrafts from VHL-mutant clear cell RCC (ccRCC) retained metabolic features of...

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Detalles Bibliográficos
Autores principales: Kaushik, Akash K., Tarangelo, Amy, Boroughs, Lindsey K., Ragavan, Mukundan, Zhang, Yuanyuan, Wu, Cheng-Yang, Li, Xiangyi, Ahumada, Kristen, Chiang, Jui-Chung, Tcheuyap, Vanina T., Saatchi, Faeze, Do, Quyen N., Yong, Cissy, Rosales, Tracy, Stevens, Christina, Rao, Aparna D., Faubert, Brandon, Pachnis, Panayotis, Zacharias, Lauren G., Vu, Hieu, Cai, Feng, Mathews, Thomas P., Genovese, Giannicola, Slusher, Barbara S., Kapur, Payal, Sun, Xiankai, Merritt, Matthew, Brugarolas, James, DeBerardinis, Ralph J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757752/
https://www.ncbi.nlm.nih.gov/pubmed/36525494
http://dx.doi.org/10.1126/sciadv.abp8293

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