How decreasing T cell signaling unexpectedly results in autoimmunity

In this issue of JEM, Tanaka et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20220386) advance our understanding of how genetic mutants that decrease T cell recognition of antigen, a critical event for immune activation to invading microbes and virus, paradoxically results in autoimmunity.

Detalles Bibliográficos
Autores principales: Yi, Jaeu, Hsieh, Chyi-Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757847/
https://www.ncbi.nlm.nih.gov/pubmed/36520516
http://dx.doi.org/10.1084/jem.20221886
Descripción
Sumario:In this issue of JEM, Tanaka et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20220386) advance our understanding of how genetic mutants that decrease T cell recognition of antigen, a critical event for immune activation to invading microbes and virus, paradoxically results in autoimmunity.

Ejemplares similares