How decreasing T cell signaling unexpectedly results in autoimmunity

In this issue of JEM, Tanaka et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20220386) advance our understanding of how genetic mutants that decrease T cell recognition of antigen, a critical event for immune activation to invading microbes and virus, paradoxically results in autoimmunity.

Detalles Bibliográficos
Autores principales: Yi, Jaeu, Hsieh, Chyi-Song
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Insights
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757847/
https://www.ncbi.nlm.nih.gov/pubmed/36520516
http://dx.doi.org/10.1084/jem.20221886
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author Yi, Jaeu
Hsieh, Chyi-Song
author_facet Yi, Jaeu
Hsieh, Chyi-Song
author_sort Yi, Jaeu
collection PubMed
description In this issue of JEM, Tanaka et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20220386) advance our understanding of how genetic mutants that decrease T cell recognition of antigen, a critical event for immune activation to invading microbes and virus, paradoxically results in autoimmunity.
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spelling pubmed-97578472023-06-15 How decreasing T cell signaling unexpectedly results in autoimmunity Yi, Jaeu Hsieh, Chyi-Song J Exp Med Insights In this issue of JEM, Tanaka et al. (2022. J. Exp. Med. https://doi.org/10.1084/jem.20220386) advance our understanding of how genetic mutants that decrease T cell recognition of antigen, a critical event for immune activation to invading microbes and virus, paradoxically results in autoimmunity. Rockefeller University Press 2022-12-15 /pmc/articles/PMC9757847/ /pubmed/36520516 http://dx.doi.org/10.1084/jem.20221886 Text en © 2022 Yi and Hsieh https://creativecommons.org/licenses/by-nc-sa/4.0/http://www.rupress.org/terms/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Insights
Yi, Jaeu
Hsieh, Chyi-Song
How decreasing T cell signaling unexpectedly results in autoimmunity
title How decreasing T cell signaling unexpectedly results in autoimmunity
title_full How decreasing T cell signaling unexpectedly results in autoimmunity
title_fullStr How decreasing T cell signaling unexpectedly results in autoimmunity
title_full_unstemmed How decreasing T cell signaling unexpectedly results in autoimmunity
title_short How decreasing T cell signaling unexpectedly results in autoimmunity
title_sort how decreasing t cell signaling unexpectedly results in autoimmunity
topic Insights
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757847/
https://www.ncbi.nlm.nih.gov/pubmed/36520516
http://dx.doi.org/10.1084/jem.20221886
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