Hyperstabilization of T cell microvilli contacts by chimeric antigen receptors

T cells typically recognize their ligands using a defined cell biology—the scanning of their membrane microvilli (MV) to palpate their environment—while that same membrane scaffolds T cell receptors (TCRs) that can signal upon ligand binding. Chimeric antigen receptors (CARs) present both a therapeu...

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Detalles Bibliográficos
Autores principales: Beppler, Casey, Eichorst, John, Marchuk, Kyle, Cai, En, Castellanos, Carlos A., Sriram, Venkataraman, Roybal, Kole T., Krummel, Matthew F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9757849/
https://www.ncbi.nlm.nih.gov/pubmed/36520493
http://dx.doi.org/10.1083/jcb.202205118

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