Mass spectrometry captures biased signalling and allosteric modulation of a G-protein-coupled receptor

G-protein-coupled receptors signal through cognate G proteins. Despite the widespread importance of these receptors, their regulatory mechanisms for G-protein selectivity are not fully understood. Here we present a native mass spectrometry-based approach to interrogate both biased signalling and all...

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Detalles Bibliográficos
Autores principales: Yen, Hsin-Yung, Liko, Idlir, Song, Wanling, Kapoor, Parth, Almeida, Fernando, Toporowska, Joanna, Gherbi, Karolina, Hopper, Jonathan T. S., Charlton, Steven J., Politis, Argyris, Sansom, Mark S. P., Jazayeri, Ali, Robinson, Carol V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9758051/
https://www.ncbi.nlm.nih.gov/pubmed/36357787
http://dx.doi.org/10.1038/s41557-022-01041-9

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