Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules

Leucine-rich repeat kinase 2 (LRRK2) is one of the most commonly mutated genes in familial Parkinson’s disease (PD). Under some circumstances, LRRK2 co-localizes with microtubules in cells, an association enhanced by PD mutations. We report a cryo-EM structure of the catalytic half of LRRK2, contain...

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Detalles Bibliográficos
Autores principales: Snead, David M., Matyszewski, Mariusz, Dickey, Andrea M., Lin, Yu Xuan, Leschziner, Andres E., Reck-Peterson, Samara L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9758056/
https://www.ncbi.nlm.nih.gov/pubmed/36510024
http://dx.doi.org/10.1038/s41594-022-00863-y

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