The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases

Despite annual increases in the incidence and prevalence of neurodegenerative diseases, there is a lack of effective treatment strategies. An increasing number of E3 ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs) have been observed to participate in the pathogenesis mechanisms of neurod...

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Autores principales: Liu, Na, Lin, Miao-Miao, Wang, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9758110/
https://www.ncbi.nlm.nih.gov/pubmed/36260224
http://dx.doi.org/10.1007/s12035-022-03063-3
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author Liu, Na
Lin, Miao-Miao
Wang, Yan
author_facet Liu, Na
Lin, Miao-Miao
Wang, Yan
author_sort Liu, Na
collection PubMed
description Despite annual increases in the incidence and prevalence of neurodegenerative diseases, there is a lack of effective treatment strategies. An increasing number of E3 ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs) have been observed to participate in the pathogenesis mechanisms of neurodegenerative diseases, on the basis of which we conducted a systematic literature review of the studies. This review will help to explore promising therapeutic targets from highly dynamic ubiquitination modification processes.
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spelling pubmed-97581102022-12-18 The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases Liu, Na Lin, Miao-Miao Wang, Yan Mol Neurobiol Article Despite annual increases in the incidence and prevalence of neurodegenerative diseases, there is a lack of effective treatment strategies. An increasing number of E3 ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs) have been observed to participate in the pathogenesis mechanisms of neurodegenerative diseases, on the basis of which we conducted a systematic literature review of the studies. This review will help to explore promising therapeutic targets from highly dynamic ubiquitination modification processes. Springer US 2022-10-19 2023 /pmc/articles/PMC9758110/ /pubmed/36260224 http://dx.doi.org/10.1007/s12035-022-03063-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Liu, Na
Lin, Miao-Miao
Wang, Yan
The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases
title The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases
title_full The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases
title_fullStr The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases
title_full_unstemmed The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases
title_short The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases
title_sort emerging roles of e3 ligases and dubs in neurodegenerative diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9758110/
https://www.ncbi.nlm.nih.gov/pubmed/36260224
http://dx.doi.org/10.1007/s12035-022-03063-3
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