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Temperature-adaptive hydrogel optical waveguide with soft tissue-affinity for thermal regulated interventional photomedicine

Photomedicine has gained great attention due to its nontoxicity, good selectivity and small trauma. However, owing to the limited penetration of light and difficult monitoring of the photo-media therapies, it is challenging to apply photomedical treatment in deep tissue as they may damage normal tis...

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Autores principales: Chen, Guoyin, Hou, Kai, Yu, Nuo, Wei, Peiling, Chen, Tao, Zhang, Caihong, Wang, Shun, Liu, Hongmei, Cao, Ran, Zhu, Liping, Hsiao, Benjamin S., Zhu, Meifang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9758120/
https://www.ncbi.nlm.nih.gov/pubmed/36526631
http://dx.doi.org/10.1038/s41467-022-35440-w
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author Chen, Guoyin
Hou, Kai
Yu, Nuo
Wei, Peiling
Chen, Tao
Zhang, Caihong
Wang, Shun
Liu, Hongmei
Cao, Ran
Zhu, Liping
Hsiao, Benjamin S.
Zhu, Meifang
author_facet Chen, Guoyin
Hou, Kai
Yu, Nuo
Wei, Peiling
Chen, Tao
Zhang, Caihong
Wang, Shun
Liu, Hongmei
Cao, Ran
Zhu, Liping
Hsiao, Benjamin S.
Zhu, Meifang
author_sort Chen, Guoyin
collection PubMed
description Photomedicine has gained great attention due to its nontoxicity, good selectivity and small trauma. However, owing to the limited penetration of light and difficult monitoring of the photo-media therapies, it is challenging to apply photomedical treatment in deep tissue as they may damage normal tissues. Herein, a thermal regulated interventional photomedicine based on a temperature-adaptive hydrogel fiber-based optical waveguide (THFOW) is proposed, capable of eliminating deeply seated tumor cells while lowering risks of overtemperature (causes the death of healthy cells around the tumor). The THFOW is fabricated by an integrated homogeneous-dynamic-crosslinking-spinning method, and shows a remarkable soft tissue-affinity (low cytotoxicity, swelling stability, and soft tissue-like Young’s modulus). Moreover, the THFOW shows an excellent light propagation property with different wavenumbers (especially −0.32 dB cm(−1) with 915 nm laser light), and temperature-gated light propagation effect. The THFOW and relevant therapeutic strategy offer a promising application for intelligent photomedicine in deep issue.
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spelling pubmed-97581202022-12-18 Temperature-adaptive hydrogel optical waveguide with soft tissue-affinity for thermal regulated interventional photomedicine Chen, Guoyin Hou, Kai Yu, Nuo Wei, Peiling Chen, Tao Zhang, Caihong Wang, Shun Liu, Hongmei Cao, Ran Zhu, Liping Hsiao, Benjamin S. Zhu, Meifang Nat Commun Article Photomedicine has gained great attention due to its nontoxicity, good selectivity and small trauma. However, owing to the limited penetration of light and difficult monitoring of the photo-media therapies, it is challenging to apply photomedical treatment in deep tissue as they may damage normal tissues. Herein, a thermal regulated interventional photomedicine based on a temperature-adaptive hydrogel fiber-based optical waveguide (THFOW) is proposed, capable of eliminating deeply seated tumor cells while lowering risks of overtemperature (causes the death of healthy cells around the tumor). The THFOW is fabricated by an integrated homogeneous-dynamic-crosslinking-spinning method, and shows a remarkable soft tissue-affinity (low cytotoxicity, swelling stability, and soft tissue-like Young’s modulus). Moreover, the THFOW shows an excellent light propagation property with different wavenumbers (especially −0.32 dB cm(−1) with 915 nm laser light), and temperature-gated light propagation effect. The THFOW and relevant therapeutic strategy offer a promising application for intelligent photomedicine in deep issue. Nature Publishing Group UK 2022-12-16 /pmc/articles/PMC9758120/ /pubmed/36526631 http://dx.doi.org/10.1038/s41467-022-35440-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Chen, Guoyin
Hou, Kai
Yu, Nuo
Wei, Peiling
Chen, Tao
Zhang, Caihong
Wang, Shun
Liu, Hongmei
Cao, Ran
Zhu, Liping
Hsiao, Benjamin S.
Zhu, Meifang
Temperature-adaptive hydrogel optical waveguide with soft tissue-affinity for thermal regulated interventional photomedicine
title Temperature-adaptive hydrogel optical waveguide with soft tissue-affinity for thermal regulated interventional photomedicine
title_full Temperature-adaptive hydrogel optical waveguide with soft tissue-affinity for thermal regulated interventional photomedicine
title_fullStr Temperature-adaptive hydrogel optical waveguide with soft tissue-affinity for thermal regulated interventional photomedicine
title_full_unstemmed Temperature-adaptive hydrogel optical waveguide with soft tissue-affinity for thermal regulated interventional photomedicine
title_short Temperature-adaptive hydrogel optical waveguide with soft tissue-affinity for thermal regulated interventional photomedicine
title_sort temperature-adaptive hydrogel optical waveguide with soft tissue-affinity for thermal regulated interventional photomedicine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9758120/
https://www.ncbi.nlm.nih.gov/pubmed/36526631
http://dx.doi.org/10.1038/s41467-022-35440-w
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