The effectiveness of ginger extract addition in calorified drinks during perioperative period to nausea severity, vomitus, post-operative anxiety, and metabolic disorder: A randomized control trial

BACKGROUND: This study was aimed to evaluate the effect of ginger extract addition to pre-operative high calorie drink to reduce nausea, vomiting, anxiety level, and lactate level as a parameter for metabolic derangement in patients undergoing surgery. MATERIALS AND METHODS: A prospective single-blinded randomized controlled trial design, with a study subject elective surgical procedures patient at the Department of Surgery, Dr Hasan Sadikin Hospital, Bandung. Patient were divided into two groups, group A with standard high calorie drink, and group B standard high calorie drink with ginger extract addition. Anxiety was measured by HARS score and the occurrence of nausea and vomiting were assessed after the operation. The difference of lactate levels was compared before and after operation in two groups. The data distribution was calculated by kolmogorov-smirnov for continues variables. Normal distribution was calculated by t-test, non-normal distribution was calculated by Mann-U Whitney. Nominal data calculated by chi-square test and ordinal data calculated by Mann-U Whitney. RESULTS: 40 subjects were randomly divided into two groups. The occurrence of nausea and vomiting were lower in group B patients (p < 0.0285). HARS score anxiety level was lowered in group B patients (p < 0.0293). Lactate level was lowered in group B patients, although is not statistically significant (p 0.54). CONCLUSION: Addition of ginger extract in pre-operative high calorie drink reduce postoperative nausea, vomiting, and anxiety level.