Systematic pharmacological analysis of agonistic and antagonistic fibroblast growth factor receptor 1 MAbs reveals a similar unique mode of action

Fibroblast growth factor receptor 1 (FGFR1) is a receptor tyrosine kinase that plays a major role in developmental processes and metabolism. The dysregulation of FGFR1 through genetic aberrations leads to skeletal and metabolic diseases as well as cancer. For this reason, FGFR1 is a promising therap...

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Detalles Bibliográficos
Autores principales: Chan, Jocelyn, Chan, Joyce, Shao, Lily, Stawicki, Scott S., Pham, Victoria C., Akita, Rob W., Hafner, Marc, Crocker, Lisa, Yu, Kebing, Koerber, James T., Schaefer, Gabriele, Comps-Agrar, Laetitia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9758440/
https://www.ncbi.nlm.nih.gov/pubmed/36410439
http://dx.doi.org/10.1016/j.jbc.2022.102729

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