High performance of the automated ADVIA Centaur Systems SARS-CoV-2 Antigen Assay in nasopharyngeal samples with high viral load

ADVIA Centaur SARS-CoV-2 Antigen (COV2Ag) Assay (Siemens Healthineers) was evaluated for SARS-CoV-2 detection. A total of 141 nasopharyngeal samples were analyzed by this technique and results were compared with those obtained by quantitative reverse-transcription polymerase chain reaction (RT-PCR)....

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Autores principales: Ríos, Esther, Medrano, Sara, Alvarez, Mar, Valderrama, María José, Vallejo, Luis, Delgado-Iribarren, Alberto, Culebras, Esther
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9758452/
https://www.ncbi.nlm.nih.gov/pubmed/36527576
http://dx.doi.org/10.1007/s10123-022-00311-3
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author Ríos, Esther
Medrano, Sara
Alvarez, Mar
Valderrama, María José
Vallejo, Luis
Delgado-Iribarren, Alberto
Culebras, Esther
author_facet Ríos, Esther
Medrano, Sara
Alvarez, Mar
Valderrama, María José
Vallejo, Luis
Delgado-Iribarren, Alberto
Culebras, Esther
author_sort Ríos, Esther
collection PubMed
description ADVIA Centaur SARS-CoV-2 Antigen (COV2Ag) Assay (Siemens Healthineers) was evaluated for SARS-CoV-2 detection. A total of 141 nasopharyngeal samples were analyzed by this technique and results were compared with those obtained by quantitative reverse-transcription polymerase chain reaction (RT-PCR). The overall sensitivity and specificity of the test were 68.70% and 70%, respectively. Regarding cycle threshold (Ct) values, the COV2Ag test showed a sensitivity of 93.75% and 100% for nasopharyngeal samples with Ct < 25 and < 20, respectively. ADVIA Centaur COV2Ag Assay is a useful, automated, and rapid technique for early SARS-CoV-2 diagnosis and isolation of the infected individuals, avoiding its transmission.
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spelling pubmed-97584522022-12-19 High performance of the automated ADVIA Centaur Systems SARS-CoV-2 Antigen Assay in nasopharyngeal samples with high viral load Ríos, Esther Medrano, Sara Alvarez, Mar Valderrama, María José Vallejo, Luis Delgado-Iribarren, Alberto Culebras, Esther Int Microbiol Research ADVIA Centaur SARS-CoV-2 Antigen (COV2Ag) Assay (Siemens Healthineers) was evaluated for SARS-CoV-2 detection. A total of 141 nasopharyngeal samples were analyzed by this technique and results were compared with those obtained by quantitative reverse-transcription polymerase chain reaction (RT-PCR). The overall sensitivity and specificity of the test were 68.70% and 70%, respectively. Regarding cycle threshold (Ct) values, the COV2Ag test showed a sensitivity of 93.75% and 100% for nasopharyngeal samples with Ct < 25 and < 20, respectively. ADVIA Centaur COV2Ag Assay is a useful, automated, and rapid technique for early SARS-CoV-2 diagnosis and isolation of the infected individuals, avoiding its transmission. Springer International Publishing 2022-12-17 2023 /pmc/articles/PMC9758452/ /pubmed/36527576 http://dx.doi.org/10.1007/s10123-022-00311-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research
Ríos, Esther
Medrano, Sara
Alvarez, Mar
Valderrama, María José
Vallejo, Luis
Delgado-Iribarren, Alberto
Culebras, Esther
High performance of the automated ADVIA Centaur Systems SARS-CoV-2 Antigen Assay in nasopharyngeal samples with high viral load
title High performance of the automated ADVIA Centaur Systems SARS-CoV-2 Antigen Assay in nasopharyngeal samples with high viral load
title_full High performance of the automated ADVIA Centaur Systems SARS-CoV-2 Antigen Assay in nasopharyngeal samples with high viral load
title_fullStr High performance of the automated ADVIA Centaur Systems SARS-CoV-2 Antigen Assay in nasopharyngeal samples with high viral load
title_full_unstemmed High performance of the automated ADVIA Centaur Systems SARS-CoV-2 Antigen Assay in nasopharyngeal samples with high viral load
title_short High performance of the automated ADVIA Centaur Systems SARS-CoV-2 Antigen Assay in nasopharyngeal samples with high viral load
title_sort high performance of the automated advia centaur systems sars-cov-2 antigen assay in nasopharyngeal samples with high viral load
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9758452/
https://www.ncbi.nlm.nih.gov/pubmed/36527576
http://dx.doi.org/10.1007/s10123-022-00311-3
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