Multi-region sequencing with spatial information enables accurate heterogeneity estimation and risk stratification in liver cancer

BACKGROUND: Numerous studies have used multi-region sampling approaches to characterize intra-tumor heterogeneity (ITH) in hepatocellular carcinoma (HCC). However, conventional multi-region sampling strategies do not preserve the spatial details of samples, and thus, the potential influences of spat...

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Detalles Bibliográficos
Autores principales: Yang, Chen, Zhang, Senquan, Cheng, Zhuoan, Liu, Zhicheng, Zhang, Linmeng, Jiang, Kai, Geng, Haigang, Qian, Ruolan, Wang, Jun, Huang, Xiaowen, Chen, Mo, Li, Zhe, Qin, Wenxin, Xia, Qiang, Kang, Xiaonan, Wang, Cun, Hang, Hualian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9758830/
https://www.ncbi.nlm.nih.gov/pubmed/36527145
http://dx.doi.org/10.1186/s13073-022-01143-6

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